TY - JOUR JF - jmpir JO - J. Med. Plants VL - 11 IS - 43 PY - 2012 Y1 - 2012/8/01 TI - Aloe vera Leaf Gel in Treatment of Advanced Type 2 Diabetes Mellitus Needing Insulin Therapy: A Randomized Double-Blind Placebo-Controlled Clinical Trial TT - Aloe vera Leaf Gel in Treatment of Advanced Type 2 Diabetes Mellitus Needing Insulin Therapy: A Randomized Double-Blind Placebo-Controlled Clinical Trial N2 - Background: Advanced type 2 diabetes mellitus (T2DM) needing insulin therapy is a common disease. Previous studies indicate that aloe (Aloe vera L.) leaf gel may positively affect the blood glucose and lipid levels in patients with advanced T2DM needing insulin. Objective: Evaluation of the efficacy and safety of aloe leaf gel in the treatment of type 2 diabetic patients resistant to oral synthetic anti-hyperglycemic drugs needing insulin. Methods: In this randomized double - blind placebo-controlled clinical trial with the patients aged 40-60 years, the efficacy and safety of taking aloe leaf gel (one 300 mg capsule every 12 hours for 2 months) combined with oral synthetic anti-hyperglycemic drugs in treatment of 35 patients were evaluated and compared with the placebo group (n = 35). Results: The aloe leaf gel lowered the blood levels of fasting glucose and glycosylated hemoglobin significantly (p = 0.041 and p = 0.023 respectively) without any significant effects on the lipid profile and liver/kidney function tests (p > 0.05) compared with placebo at the endpoint. No adverse effects were reported. Conclusion: The results suggest that aloe leaf gel may safely improve glycemic control in patients with advanced T2DM needing insulin. SP - 19 EP - 27 AU - Fallah Huseini, H AU - Kianbakht, S AU - Hajiaghaee, R AU - Afkhami-Ardekani, M AU - Bonakdaran, A AU - Hashem Dabaghian, F AD - Department of Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR KW - Aloe vera KW - Glycemic control KW - Patient KW - Type 2 diabetes UR - http://jmp.ir/article-1-139-fa.html ER -