TY - JOUR T1 - Zebra Fish: Technology for Natural Product Discovery TT - ماهی زبرا: فنآوری کشف و ارزیابی ترکیبات طبیعی JF - jmpir JO - jmpir VL - 8 IS - 32 UR - http://jmp.ir/article-1-343-en.html Y1 - 2009 SP - 14 EP - 24 KW - Zebra fish KW - < KW - i> KW - Danio rerio< KW - /i> KW - Natural products N2 - Rising challenges in the present drug discovery model are prompting Prompt a renewed interest in natural products as a source of novel, bioactive small molecules. With the current validation of zebra fish as a biomedical appropriate model for functional genomics and in vivo drug discovery, the zebra fish bioassay-guided identification of natural products may be an attractive tactic to generate new lead compounds in a number of indication regions. Here, we review recent natural product research using zebra fish and evaluate the potential of this vertebrate model as a discovery platform for the systematic identification of bioactive natural products. M3 ER -