TY - JOUR T1 - Anti-ulcer and acute toxicity effects of Anethum graveolens L. aerial parts extracts in mice TT - بررسی اثر ضد زخم معده عصاره آبی و هیدروالکلی تخم شوید در موش کوچک JF - jmpir JO - jmpir VL - 1 IS - 2 UR - http://jmp.ir/article-1-815-en.html Y1 - 2002 SP - 53 EP - 64 KW - Anethum graveolens seed KW - peptic ulcer KW - cimetidine KW - sucralfate KW - mucose protection N2 - Anti-ulcer and acute toxicity effect of Anethum graveolens seed aqueous and ethanolic extracts were studied in mice. Gastric mucosal lesions were induced by oral administration of HCL (1 N) and absolute ethanol to mice. The acidity of gastric juice was measured in pyloric ligated mice. LD50 values of the aqueous and ethanolic extracts were 3.04 g/kg, i.p. (5.69, 6.16) and 6.98 g/kg, i.p. (5.69, 8.56), respectively. The efficacy of high dose of extracts (p.o.) was similar to sucralfate. The acidity was reduced by the orally or intraperitoneally administration of the extracts. The results suggest that A. graveolens seed extracts have significant antisecretory and mucosal protective effects in mice. M3 ER -