AU - Darabi, P AU - Tavakoli-far, B AU - Vaezi, Gh AU - Keramati, K TI - Effects of Intracerebroventricular Injection of Alcoholic Extract of hawthorn (Crataegus melanocarpa carpa) Leaves on Fear Behavior in Presence Pentylenetetrazole (PTZ) in Adult Male Rat PT - JOURNAL ARTICLE TA - jmpir JN - jmpir VO - 11 VI - 44 IP - 44 4099 - http://jmp.ir/article-1-134-en.html 4100 - http://jmp.ir/article-1-134-en.pdf SO - jmpir 44 ABĀ  - Background: In traditional medicine “Crataegus melano carpa” is one of the medicinal plants that has many therapeutic effects. One of them is its effect on nerveous system. Objective: Evaluation of Intracerebroventricular (ICV) injection of alcoholic extract of “Crataegus melano carpa” leaves on fear behavior in presence pentylenetetrazole (PTZ) in adult male rat. Methods: Animals were divided into 3 groups: experimental, saline and, pentylenetetrazole (PTZ) 20 mg/kg as positive control (I.P). In the experimental group, the animals received 4000 µg/Rat alcoholic extract of “Crataegus melano carpa” leaves (ICV) and PTZ (I.P). Then plus maze was used for evaluation of the fear. Open arm entries percentage (%OAE) and open arm time percentage (%OAT) were evaluated. Results: The results show that intracerebroventricular (ICV) injection of alcoholic extract of “Crataegus melano carpa” leaves increased %OAE and %OAT significantly (p<0.05). Conclusion: We concluded that alcoholix extract of “Crataegus melano carpa” is effective on fear reduction in presence pentylenetetrazole (PTZ) in adult male rat. CP - IRAN IN - Alborz University of Medical Science, Karaj, Iran, Tel: +98 - 26 - 34336007 LG - eng PB - jmpir PG - 202 PT - Research YR - 2012