year 2, Issue 7 (9-2003)
J. Med. Plants 2003, 2(7): 43-48 |
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Karimi G, Hosseinzadeh H, Bakhtiyari H. Study of anticonvulsant activity of Valeriana officinalis roots and rhizomes hydroalcoholic extract in mice and relation to nitric oxide. J. Med. Plants 2003; 2 (7) :43-48
URL: http://jmp.ir/article-1-772-en.html
URL: http://jmp.ir/article-1-772-en.html
1- School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. , gho_karimi@yahoo.com
2- School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
2- School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Abstract: (5712 Views)
The anticonvulsant effect of Valeriana officinalis roots and rhizomes hydroalcoholic extract was studied, utilizing maximal electroshock (MES) and pentylenetetrazole (PTZ) tests. In the PTZ test, the extract (0.3-3 g/kg, ip) increased the onset time of Tonic Hind Limb Extension dose-dependently. In the MES test, neither of doses showed antiseizure activity. L-NAME (1-10 mg/kg ip) reduced the anticonvulsant effect of extract in the PTZ test. The results suggest that Valeriana officinalis extract could be a candidate for treatment of petitmal seizure and nitric oxide may be involved in this effect.
Type of Study: Research |
Subject:
Pharmacology & Toxicology
Received: 2002/05/12 | Accepted: 2003/07/20 | Published: 2003/09/20
Received: 2002/05/12 | Accepted: 2003/07/20 | Published: 2003/09/20
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