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:: Volume 2, Number 14 (6-2005) ::
JMP 2005, 2(14): 53-57 Back to browse issues page
Taxezopidine-G from needles and young stems of Taxus baccata L. growing in Iran
M Pirali-Hamedani1, Verdian Rizi MR2, SH Rezazadeh *3, R Dowlatabadi1, A Hadjiakhoondi4, M Amini1, D Yazdani5
1- (Ph.D.) 1- Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran university of Medical Sciences (TUMS), Tehran, Iran
2- (Pharm.D.) 1- Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran university of Medical Sciences (TUMS), Tehran, Iran
3- (Pharm.D.) 2- Institute of Medicinal Plants, No 97, Bozorgmehr St, Qods St, Enghelab Ave, Tehran, Iran , shrezazadeh@yahoo.com
4- (Ph.D.) 3- Department of Pharmacognosy, Faculty of Pharmacy and Medicinal plants Research Center, Tehran university of Medical Sciences (TUMS), Tehran, Iran
5- (M.Sc.) 2- Institute of Medicinal Plants, No 97, Bozorgmehr St, Qods St, Enghelab Ave, Tehran, Iran
Abstract:   (1642 Views)
Background: Taxus species are important due to their content of Taxol, baccatin III, 10- deacetyl baccatin and other taxoids suitable to change to active pharmaceutical ingredients, which are used as anti-neoplastic agents. Investigations on taxoids carried out during the past four decades, resulted in identification of more than 350 taxoids. Objective: This study aimed to isolate and identify taxoids of Taxus baccata endogenous to the north of Iran. Method: Removing of fats, extraction of components with an organic solvent and then separation and purification of components with silica gel based column chromatography was done. Identification was carried out using NMR spectra of components. Results: Taxezopidine-G was separated and identified. Conclusion: Taxezopidine-G in Taxus baccata was isolated which had not been repoted in this spcies, previously.
Keywords: Taxus baccata L., Taxezopidine-G
Full-Text [PDF 118 kb]   (640 Downloads)    
Type of Study: Research | Subject: Medicinal Chemistry
Received: 2014/12/8 | Accepted: 2014/12/8 | Published: 2014/12/8
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Pirali-Hamedani M, Verdian Rizi MR, Rezazadeh S, Dowlatabadi R, Hadjiakhoondi A, Amini M et al . Taxezopidine-G from needles and young stems of Taxus baccata L. growing in Iran. JMP. 2005; 2 (14) :53-57
URL: http://jmp.ir/article-1-710-en.html
Volume 2, Number 14 (6-2005) Back to browse issues page
فصلنامه علمی پژوهشی گیاهان دارویی Journal of Medicinal Plants
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