:: Volume 3, Number 51 (9-2014) ::
JMP 2014, 3(51): 26-32 Back to browse issues page
Efficacy of Melaleuca alternifolia Essential Oil in the Treatment of Facial Seborrheic Dermatitis: A Double-blind, Randomized, Placebo-Controlled Clinical Trial
A Beheshti Roy1, B Tavakoli-far *2, H Fallah Huseini3, P Tousi4, N Shafigh4, M Rahimzadeh5
1- (Dermatologist.) Dermatology Department, Boali Hospital, Qazvin University of Medical Science, Qazvin, Iran
2- (Ph.D.) Physiology and Pharmacology Department, Alborz University of Medical Science, Karaj, Iran , tavakkolifarb@yahoo.com
3- (Ph.D.) Pharmacology & Applied Medicine Department of Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
4- (M.D.) Dermatology Department, Boali Hospital, Qazvin University of Medical Science, Qazvin, Iran
5- (Ph.D.) Department of Social Determination of Health Research Center, Alborz University of Medical Science, Karaj, Iran
Abstract:   (2716 Views)
Background: Melaleuca alternifolia (tea tree) essential oil has been traditionally used in the ayurvedic system of medicine for healing burns, infections and seborrheic dermatitis. But yet, no controlled human study has determined its efficacy. Objective: The goal of the current study was to compare the efficacy of 5% tea tree essential oil (TTO) gel with placebo in the treatment of mild to moderate facial seborrheic dermatitis. Methods: Fifty four patients with mild to moderate facial seborrheic dermatitis reffered to Skin Diseases Research Center, in the Qazvin city, Iran, were randomly divided into two groups and treated with either 5% TTO gel or placebo three times daily for 4 weeks. The patients follow-ups were conducted in both groups after 2 and 4 weeks with evaluating of erythema, scaling, itching and greasy crusts. Results: Forty two patients completed the treatment course. There were significant differences between the TTO and placebo groups in the improvement of erythema, scaling, itching and greasy crusts (p < 0.05). Allergic side - effects were seen in neither group. Conclusions: 5% TTO gel is effective in the treatment of mild to moderate facial seborrheic dermatitis.
Keywords: Melaleuca alternifolia, Facial seborrheic dermatitis, Tea tree oil gel, Topical treatment
Full-Text [PDF 143 kb]   (1099 Downloads)    
Type of Study: Research | Subject: Pharmacology
Received: 2014/12/1 | Accepted: 2014/12/1 | Published: 2014/12/1



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Volume 3, Number 51 (9-2014) Back to browse issues page