[صفحه اصلی ]   [Archive] [ English ]  
:: صفحه اصلي :: درباره نشريه :: آخرين شماره :: تمام شماره‌ها :: جستجو :: ثبت نام :: ارسال مقاله :: تماس با ما ::
:: دوره 1، شماره 29 و S5 - ( ويژه نامه شماره 5 (به زبان انگليسي) 1387 ) ::
جلد 1 شماره 29 و S5 صفحات 57-64 برگشت به فهرست نسخه ها
Protective Effects of Quercetin on Spermatogenesis in Streptozotocin-induced Diabetic Rat
چکیده:   (2309 مشاهده)

  Background: Quercetin is a strong antioxidant and long-term treatment of STZ-diabetic animals and it has been shown to reduce oxidative stress.

  Objective: antioxidants have essential effect on spermatogenesis and sperm parameters. Enhanced oxidative stress and changes in antioxidant capacity are considered to play an important role in the pathogenesis of chronic diabetes mellitus.

  Methods: Wistar male rat (n=40) were allocated into three groups, control group (n=10) and Quercetin (QR) group that received 15mg/kg (IP) QR, (n=10), and Diabetic group that received 55 mg/kg (IP) streptozotocin (STZ) (n=20) which was subdivided to two groups of 10 STZ group and treatment group. Treatment group received 55 mg/kg (IP) STZ plus15mg/kg QR, daily for,4 weeks, respectively however, the control group just received an equal volume of distilled water daily (IP). Diabetes was induced by a single intra peritonea injection of streptozotocin (55 mg/kg). Animals were kept in standard condition. In 28day after inducing diabetic 5cc blood were collected for testosterone, TAC, MDA and Ox-LDL levels and testes tissues of Rat in whole groups were removed and sperm was collected from epididymis then prepared for analysis.

  Results: Sperm population, percentage of sperm viability and motility significantly increased in group that has received 15 mg/kg (IP) Quercetin (p<0.05) in comparison to control and experimental groups.

Conclusion: Since in our study 15 mg/kg (IP) Quercetin have significantly Preventive effect on Sperm percentage of viability and motility by reducing level of Reactive Oxygen Species (ROS) in serum, so it seems that using it can be effective for sperm healthy parameters in Diabetic Rat.
متن کامل [PDF 143 kb]   (1202 دریافت)    
نوع مطالعه: پژوهشي | موضوع مقاله: دامپزشكي
دریافت: ۱۳۹۳/۹/۲ | پذیرش: ۱۳۹۳/۹/۲ | انتشار: ۱۳۹۳/۹/۲
ارسال نظر درباره این مقاله
نام کاربری یا پست الکترونیک شما:

CAPTCHA code


XML   English Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Khaki A, Nouri M, Fathiazad F, Ahmadi-Ashtiani H, Rastgar H, Rezazadeh S. Protective Effects of Quercetin on Spermatogenesis in Streptozotocin-induced Diabetic Rat. JMP. 2009; 1 (29) :57-64
URL: http://jmp.ir/article-1-536-fa.html

Protective Effects of Quercetin on Spermatogenesis in Streptozotocin-induced Diabetic Rat. فصلنامه گياهان دارويي. 1387; 1 (29) :57-64

URL: http://jmp.ir/article-1-536-fa.html



دوره 1، شماره 29 و S5 - ( ويژه نامه شماره 5 (به زبان انگليسي) 1387 ) برگشت به فهرست نسخه ها
فصلنامه علمی پژوهشی گیاهان دارویی Journal of Medicinal Plants
Persian site map - English site map - Created in 0.05 seconds with 31 queries by YEKTAWEB 3764