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:: دوره 1، شماره 33 و S 6 - ( ويژه نامه شماره 6 (به زبان انگليسي) 1388 ) ::
جلد 1 شماره 33 و S 6 صفحات 107-112 برگشت به فهرست نسخه ها
Compartments of Quercetin & Allium cepa (Onion) on Blood Glucose in Diabetic Rats
چکیده:   (2203 مشاهده)

  Background : The major concern in diabetes is increased oxidative stress. Maintaining a balance between reactive oxygen species (ROS) and antioxidants is a major mechanism in preventing damage from oxidative stress. Quercetin (QR) is a well-known flavonoid and a strong antioxidant derived from the onion, Allium cepa, and it has been shown to reduce oxidative stress in the long-term treatment of streptozotocin (STZ)-induced diabetes in animals.

  Objective: We aimed to study on beneficial effects of QR & Allium cepa on regulation of blood glucose in diabetic model.

  Methods : Seventy male 8-week-old Wistar albino rats weighing 250 ± 10 g were obtained, the rats were divided into seven groups comprising ten animals in each group. Diabetes induced with single intraperitoneal injection of STZ. Diabetic rats treated with quercetin (15mg/kg/day, started 48 hours after STZ injection) and Allium cepa juice (2cc/rat/day, started 48 hours after STZ injection). After 28 days treatment, analysis on blood glucose and insulin was done.

  Results : The mean TAC showed a significant increase (p < 0.05) in the QR compared to the control, STZ and STZ + QR groups. Both QR and onion Juice had significant effect in lowering blood glucose (355.3 ± 104 mg/dl and 353.4 ± 103 mg/dl respectively) (p<0.05) in STZ induced diabetic animals. Both QR and onion juice had lowering effect in Serum insulin in healthy animals and significant increasing effect on serum insulin level in diabetic animals.

Conclusions : Both QR and onion juice had good effect in modifying diabetes related biochemical parameters and they are recommended to be studied more in order to being used in the therapy.
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نوع مطالعه: پژوهشي | موضوع مقاله: دامپزشكي
دریافت: ۱۳۹۳/۹/۱ | پذیرش: ۱۳۹۳/۹/۱ | انتشار: ۱۳۹۳/۹/۱
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Khaki A, Fathiazad F, Ahmadi - Ashtiani H, Rezazadeh S, Rastegar H, Imani A. Compartments of Quercetin & Allium cepa (Onion) on Blood Glucose in Diabetic Rats. JMP. 2010; 1 (33) :107-112
URL: http://jmp.ir/article-1-521-fa.html

Compartments of Quercetin & Allium cepa (Onion) on Blood Glucose in Diabetic Rats. فصلنامه گياهان دارويي. 1388; 1 (33) :107-112

URL: http://jmp.ir/article-1-521-fa.html



دوره 1، شماره 33 و S 6 - ( ويژه نامه شماره 6 (به زبان انگليسي) 1388 ) برگشت به فهرست نسخه ها
فصلنامه علمی پژوهشی گیاهان دارویی Journal of Medicinal Plants
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