:: دوره 1، شماره 33 و S 6 - ( ويژه نامه شماره 6 (به زبان انگليسي) 1388 ) ::
جلد 1 شماره 33 و S 6 صفحات 86-96 برگشت به فهرست نسخه ها
Evaluation of Protective Effects of Nano-formulated Silymarin Against UV Radiation on Guinea Pig Skin
چکیده:   (2170 مشاهده)

  Background: As increased outdoor activities of people, they are more exposed to UV radiation, which causes harmful effects on skin. Silymarin has protective potentials against DNA damage and non-melanoma skin cancers, and also it has anti-oxidant, anti-inflammatory, and immune regulation characteristics. Nano formulation of plant material showed to be more effective than common ones.

  Objective: In present study, nano-formulated silymarin was used in a cream, and its effects were investigated against destructive effects of UV rays.

  Methods: Silymarin standardized extract was prepared, nano formulated in cream base, and applied to skin of the animals. Four groups of animals (n=15) were examined Group 1 without any treatment (control), Group 2 Vaseline, Group 3 nano-formulated silymarin extract cream, and Group 4 silymarin-carnosine. UV was radiated on the shaved area of the four groups for 45 minutes with dose of 180 mJ/cm2. Dermal scaling, skin irregularity, erythema, skin hyperpigmentation, and edema were evaluated in animals. Histopathological observation was done on the skin samples of the animals.

  Results: silymarin nano-formulation was effective in decreasing both physical damages and histopathological injuries significantly.

Conclusion: from the observed results, it can be concluded that the cream containing nano-formulated silymarin can prevent UV radiation lesions better than pure silymarin.
متن کامل [PDF 374 kb]   (633 دریافت)    
نوع مطالعه: پژوهشي | موضوع مقاله: كنترل غذا و دارو
دریافت: ۱۳۹۳/۹/۱ | پذیرش: ۱۳۹۳/۹/۱ | انتشار: ۱۳۹۳/۹/۱


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دوره 1، شماره 33 و S 6 - ( ويژه نامه شماره 6 (به زبان انگليسي) 1388 ) برگشت به فهرست نسخه ها