year 9, Issue 33 And S6 (supplement 6 2010)                   J. Med. Plants 2010, 9(33 And S6): 29-34 | Back to browse issues page

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Hajimehdipoor H, Sadat-Ebrahimi S, Amanzadeh Y, Izaddoost M, Givi E. Identification and Quantitative Determination of 4-Hydroxyisoleucine in Trigonella foenum-graecum L. from Iran. J. Med. Plants 2010; 9 (33) :29-34
URL: http://jmp.ir/article-1-505-en.html
Identification and Quantitative Determination of 4-Hydroxyisoleucine in Trigonella foenum-graecum L. from Iran
H Hajimehdipoor1 , SE Sadat-Ebrahimi * 2, Y Amanzadeh3 , M Izaddoost3 , E Givi4
1- Traditional Medicine and Materia Medica Research Center, Shahid Beheshti University of Medical Sciences, Tehran
2- Department of Medicinal Chemistry and Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran , sesebrahimi@sina.tums.ac.ir
3- Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran
4- Department of Medicinal Chemistry and Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran
Abstract:   (4929 Views)

  Background: The seeds of Trigonella foenum-graecum L. (Fenugreek) are used in Iranian traditional medicine as blood sugar lowering agent. According to last investigations, hypoglycemic property is related to the amino acids of the plant specially 4-hydroxyisoleucine.

  Objective: In this research, identification and quantitative determination of 4-hydroxyisoleucine in Fenugreek seeds from Shahreza, central part of Iran, has been investigated.

  Methods: Powdered seeds of the plant were defatted and then extracted by using ethanol 50%. In order to isolation of 4-hydroxyisoleucine from the extract, ion exchange chromatography was used and the amino acid content was determined by using high performance liquid chromatography technique.

  Results: The results showed the presence of 0.4% 4-hydroxyisoleucine in the plant seeds which is considerable amount of the amino acid in the plant collected from Iran.

Conclusion: According to the effects of 4-hydroxyisoleucine such as antihyperglycemic and antihyperlipidemic properties, fenugreek can be considered as an herbal remedy in supportive treatment of these disorders.
Keywords: <, i>, Trigonella foenum-graecum<, /i>, Amino acid, Diabetes, 4-hydroxyisoleucine
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Type of Study: Research | Subject: Pharmacognosy & Pharmaceutics
Received: 2009/12/8 | Accepted: 2010/02/20 | Published: 2010/03/19
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