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1- School of Sciences, Islamic Azad University of Mashhad
2- Faculty of Sciences, Ferdowsi University of Mashhad ,
Abstract:   (10034 Views)

Background: Since long lasting administration of anti-seizure drugs produces undesirable side effects, many efforts have been made during recent decades to find and replace the chemical drugs by medicinal plants.

Objective: The aim of present study was to study the antiepileptic (anti-seizure) effects of hydroalcoholic extract of Melissa officinalis on experimental epileptiform seizures, induced by pentylenetetrazol (PTZ) in Wistar rat.

Methods: After normalization, rats in experimental groups 1, 2 and 3 were injected (i.p) 50, 80 and 120 mg/kg hydroalcoholic extract of Melissa officinalis , respectively. Control animals were injected extract solvent as the same manner. After 30 minutes all rats were injected (i.p) 80 mg/kg PTZ and then examined for epileptiform behaviors for the next 60 minutes. The rate of mortality during the next 24 hour was also recorded.

Results: In comparison with control group, in all experimental groups the latent period of tonic-clonic generalized seizure was significantly (P<0.05) increased. Moreover, the mortality rate was decreased from 90% in control group to 30, 50 and 60% in experimental groups 1, 2 and 3, respectively.

Conclusions: I t can be concluded that hydroalcoholic extract of Melissa officinalis has potential sedative and anticonvulsant effects and probably exerts its effects through GABAergic system.
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Type of Study: Research | Subject: Pharmacology & Toxicology
Received: 2010/04/15 | Accepted: 2011/09/11 | Published: 2011/11/21

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