year 21, Issue 84 (12-2022)
J. Med. Plants 2022, 21(84): 13-25 |
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Tajabadi F, Rezazadeh S, Ghasemi S V, Abedinpour M, Sharifi M, Pirali Hamedani M, et al . Post-marketing control of Matricaria chamomilla L. and Thymus vulgaris L. products by reference and developed methods. J. Med. Plants 2022; 21 (84) :13-25
URL: http://jmp.ir/article-1-3408-en.html
URL: http://jmp.ir/article-1-3408-en.html
Fateme Tajabadi * 
1, Shamsali Rezazadeh2 , Seyed Vahid Ghasemi2 , Mehrnoosh Abedinpour3 , Monireh Sharifi3 , Mostafa Pirali Hamedani4 , Amirhosein Jamshidi5 , Darab Yazdani2
1, Shamsali Rezazadeh2 , Seyed Vahid Ghasemi2 , Mehrnoosh Abedinpour3 , Monireh Sharifi3 , Mostafa Pirali Hamedani4 , Amirhosein Jamshidi5 , Darab Yazdani2
1- Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran , tajabadi@imp.ac.ir
2- Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
3- Pharmaceutical Sciences Branch Faculty of Pharmacy, Islamic Azad University, Tehran, Iran
4- Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
5- Research Institute for Islamic and Complementary Medicine, Iran University of Medical Sciences, Tehran, Iran
2- Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
3- Pharmaceutical Sciences Branch Faculty of Pharmacy, Islamic Azad University, Tehran, Iran
4- Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
5- Research Institute for Islamic and Complementary Medicine, Iran University of Medical Sciences, Tehran, Iran
Abstract: (1669 Views)
Background: Post-market surveillance (PMS) is an integral part of ongoing safety evaluation, for natural health products. Matricaria chamomilla (chamomile) and Thymus vulgaris (thyme) are the most widely used plants in herbal medicinal products. Thymus species contain phenolic compounds such as thymol, carvacrol and terpenoids, flavonoids, and saponins. T. vulgaris is an antiseptic and antitussive, so it is very effective in treating dry coughs, colds, and inflammation of the upper respiratory tract. Matricaria chamomilla (chamomile) products containing apigenin-7-glycoside, some flavonoids and chamazulene in its essential oil that have anti-inflammatory, anti-fungal and anti-bacterial therapeutic properties. Objective: In this study, various dosage forms containing thyme (8 products) and chamomile (9 products) separately, (which are available in the form of drops, syrups, ointments, and creams) were provided. Then, physicochemical controls were performed based on the reference methods of herbal pharmacopeias and in-house validated methods to ensure quality and stability of these products. Methods: Since many of these products have no special monograph in pharmacopeias, so validated extraction and analysis methods were developed to quantify the apigenin-7-glycoside by high performance liquid chromatography, and chamazulene by gas chromatography in the chamomile products and thymol and carvacrol by gas chromatography in thyme products in different complex dosage forms. Results: In some products that formulated by thyme and chamomile products, the amount reported for standardization does not match the values obtained. Conclusion: It’s recommended more control of herbal medicines for appropriate and effective consumption of them.
Keywords: Thymus vulgaris, Matricaria chamomilla, PMS, Microextraction, Natural products, Quality control tests
Type of Study: Research |
Subject:
Pharmacognosy & Pharmaceutics
Received: 2022/08/14 | Accepted: 2022/10/11 | Published: 2022/12/1
Received: 2022/08/14 | Accepted: 2022/10/11 | Published: 2022/12/1
References
1. Boateng MA, Danso-Appiah A, Turkson BK and Tersbol BP. Integrating biomedical and herbal medicine in Ghana-experiences from the Kumasi South Hospital: A qualitative study. BMC Complement. Altern. Med. 2016; 16: 189-196. [DOI:10.1186/s12906-016-1163-4]
2. World Health Organization, WHO traditional medicine strategy: 2014-2023.
3. Harkey MR, Henderson GL and Gershwin ME, Stern JS and Hackman RM. Variability in commercial ginseng products: An analysis of 25 preparations. Am. J. Clin. Nutr. 2001; 73(6), 1101-1106. [DOI:10.1093/ajcn/73.6.1101]
4. Ko RJ. Adulterants in Asian patent medicines. N. Engl. J. Med. 1998; 339: 847-853. [DOI:10.1056/NEJM199809173391214]
5. Boullata JI and Nace AM. Safety issues with herbal medicine. Pharmacotherapy 2000; 20(3): 257-269. [DOI:10.1592/phco.20.4.257.34886]
6. Skoulidis F, Alexander GJM and Davies SE. Ma huang associated acute liver failure requiring liver transplantation. Eur. J. Gastroenterol. Hepatol. 2005; 17(5): 581-4. [DOI:10.1097/00042737-200505000-00017]
7. Nie J, Wang F and Ji T, Zhao J and Zhao F. Assessment of in vitro cardiotoxicity of extract fractions and diterpene alkaloids from Aconitum leucostomum Worosch: A short communication. J. Pharm. Biomed. Anal. 2017; 137: 84-89. [DOI:10.1016/j.jpba.2017.01.003]
8. Navarro VJ, Barnhart H and Bonkovsky HL, Davern T, Fontana RJ, Grant L, Reddy KR, Seeff LB, Serrano J, Sherker AH, Stolz A, Talwalkar J, Vega M and Vuppalanchi R. Liver injury from herbals and dietary supplements in the U.S. Drug-Induced Liver Injury Network. Hepatol. 2014; 60(4): 1399-1408. [DOI:10.1002/hep.27317]
9. Mojab F, Shafaati A, Nickavar B and Karimian L. Physicochemical quality control of senna products from Iranian phytopharmaceutics. J. Med. Plants 2005; 4(14): 30-35.
10. Srivastava JK, Shankar E and Gupta S. Chamomile: a herbal medicine of the past with a bright future. Mol. Med. Rep. 2010; 3: 895-901. [DOI:10.3892/mmr.2010.377]
11. Fonseca FN and Tavares MFM. Validation of a capillary electrophoresis method for the quantitative determination of free and total apigenin in extracts of Chamomilla recutita. Phytochem. Anal. 2004; 15(1): 65-70. [DOI:10.1002/pca.744]
12. Guimarães R, Barros L, Dueñas M, Calhelha RC, Carvalho AM,-Buelga CS, Queiroz MJRP and Ferreira ICFR. Infusion and decoction of wild German chamomile: bioactivity and characterization of organic acids and phenolic compounds. Food Chem. 2013; 136(2): 947-54. [DOI:10.1016/j.foodchem.2012.09.007]
13. Petronilho S, Maraschin M, Coimbra MA and Rocha SM. In vitro and in vivo studies of natural products: a challenge for their valuation. The case study of chamomile (Matricaria recutita L.), Ind. Crops. Prod. 2012; 40: 1-12. [DOI:10.1016/j.indcrop.2012.02.041]
14. British Herbal Medicine Association, British Herbal Pharmacopeia, British Herbal Medicine Association, 4th edition, 1996.
15. Mavandi P and Zarifi E. Karyomorphological study and its correlation with the quantity and quality of essential oil in Iranian chamomile accessions (Matricaria chamomilla L.). Biocatal. Agricul. Biotech. 2022; 41. 102320-8. [DOI:10.1016/j.bcab.2022.102320]
16. Loggia RD, Carle R, Sosa S and Tubaro A. Evaluation of the anti-inflammatory activity of Chamomile preparations. Planta Med. 1990; 56(6): 657-658. [DOI:10.1055/s-2006-961313]
17. Alqarni MH, Salkini AA, Abujheisha KY, Daghar MF, Al-khuraif FA and Abdel-Kader MS. Qualitative, quantitative and antimicrobial activity variations of the essential oils isolated from Thymus vulgaris and Micromeria fruticosa samples subjected to different drying conditions. Arab. J. Sci. Engin. 2022; 47: 6861-7. [DOI:10.1007/s13369-021-06469-8]
18. Rúa J, Valle PD, Arriaga DD, Fernández-Álvarez L and García-Armesto MR. Combination of carvacrol and thymol: antimicrobial activity against Staphylococcus aureus and antioxidant activity. Foodborne Pathog. Dis. 2019; 16(9): 622-629. [DOI:10.1089/fpd.2018.2594]
19. FDA, Electronic Code of Federal Regulations (e-CFR). Part 182-Substances generally recognized as safe, Section 182.20-Essential oils, oleoresins (solvent-free), and natural extractives (including distillates). Title 21, revised as of October 10, Electronic Code of Federal Regulations 2019; 3.
20. EURL, European :union: Reference Laboratory for Feed Additives (EURL-FA), Evaluation Report on the Analytical Methods Submitted in Connection With the Application for Authorisation of a Feed Additive According to Regulation (EC) No. 2016.
21. Ghasemi Dehkordi NA, Sajadi SE, Ghanadi AR, Amanzadeh Y, Azadbakht M, Asghari GR, Amin GR, Haji Akhoundi A and Taleb AM. Iranian herbal pharmacopoeia, Thymus daenensis Celak, (2002) 44-50.
22. Rezaee Moghadam N, Arefhosseini SR and Javadi A. Determination of Enrofloxacin and Ciprofloxacin residues in five different kind of chicken tissues by dispersive liquid-liquid microextraction coupled with HPLC. Iran. J. Pharm. Res. 2018; 17(4): 1182-1190.
23. Tarasoli Z, Faraji H, Tajabadi F, Shabani M and Shahbazi HR. Evaluation of adulteration in Lavandula angustifolia Mill. Products using GC/MS combined with chemometric methods. J. Med. Plants 2021; 20(80): 34-46. [DOI:10.52547/jmp.20.80.34]
24. British Pharmacopea. The department of health, social services and public safety. 2017; IV: 284.
25. Gutfinger T. Polyphenols in olive oils. JAOCS. 1981; 58: 966-968. [DOI:10.1007/BF02659771]
26. Yoo KM, Lee CH, Lee H, Moon B and Lee CY. Relative antioxidant and cytoprotective activities of common herbs. Food Chem. 2008; 106(3): 929-936. [DOI:10.1016/j.foodchem.2007.07.006]
27. Guzelmeric E, Ristivojevi P, Vovk I, Milojković-Opsenica D and Erdem Yesilada E. Quality assessment of marketed chamomile tea products by avalidated HPTLC method combined with multivariate analysis. J. Pharm. Biomed. Anal. 2017; 132: 35-45. [DOI:10.1016/j.jpba.2016.09.030]
28. Miguel FG, Cavalheiro AH, Spinola NF, Ribeiro DL, Barcelos GRM, Antunes LMG, Hori JI, Marquele-Oliveira F, Rocha BA and Berretta AA. Validation of a RP-HPLC-DAD method for chamomile (Matricaria recutita) preparations and assessment of the marker, Apigenin-7-glucoside, safety and anti-inflammatory effect. Evid-Based Complement. Alternat. Med. 2015; 5: 1-9. [DOI:10.1155/2015/828437]
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