year 21, Issue 82 (5-2022)                   J. Med. Plants 2022, 21(82): 80-92 | Back to browse issues page

Ethics code: IR.SBMU.PHARMACY.REC.1397.194


XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Bolourchian N, Shirvani S, Mojab F. Development and evaluation of taste-masked pellets loaded with Matricaria chamomilla L. extract. J. Med. Plants 2022; 21 (82) :80-92
URL: http://jmp.ir/article-1-3317-en.html
1- Department of Pharmaceutics and Pharmaceutical Nanotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran , bolourchian@sbmu.ac.ir
2- Department of Pharmaceutics and Pharmaceutical Nanotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3- Department of Pharmacognosy, Department of Pharmacognosy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, IranSchool of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract:   (1626 Views)
Background: Remarkable properties of Matricaria chamomilla L. (Mch) have caused it to be considered widely in the treatment of different ailments including gastrointestinal disorders. Objective: In the present study, the Mch extract-loaded coated pellets were developed with the aim to mask its bitter taste and to improve its dosing flexibility and patient compliance, especially in children. Methods: The plant extract was obtained by maceration with ethanol 70 % and dried using rotary evaporating and freeze drying methods. Then it was used for pellet preparation along with different proportions of various additives such as Avicel, starch and lactose by extrusion-spheronization technique. The pellets were analyzed for their size, sphericity, aspect ratio and friability. The optimized formulation, subjected for coating by Eudragit E, was evaluated for taste-masking efficiency, dissolution and morphology. Results: The optimized pellets were produced with particle size, sphericity and aspect ratio equal to 1.13 mm, 0.924 and 1.172, respectively. Low friability, suitable flow properties (carr’s index = 3.01 %) as well as dissolution led this sample to be considered for taste-masking coating. Based on in vitro dissolution studies, although the coating layer significantly decreased the release of the components at higher pH compared to the uncoated particles, acceptable dissolution was observed at pH 1.2. Appropriate taste-masking of the product was also confirmed by in vivo analysis. Conclusion: The taste-masked Mch-loaded pellets with suitable characteristics could be an appropriate delivery system with improved patient compliance.
Full-Text [PDF 607 kb]   (810 Downloads)    
Type of Study: Research | Subject: Pharmacognosy & Pharmaceutics
Received: 2022/04/9 | Accepted: 2022/05/26 | Published: 2022/05/31

References
1. Singh O, Khanam Z, Misra N and Srivastava MK. Chamomile (Matricaria chamomilla L.): an overview. Pharmacogn. Rev. 2011; 5(9): 82-95. [DOI:10.4103/0973-7847.79103]
2. Alibabaei Z, Rabiei Z, Rahnama S, Mokhtari S and Rafieian-kopaei M. Matricaria chamomilla extract demonstrates antioxidant properties against elevated rat brain oxidative status induced by amnestic dose of scopolamine. Biomed. Aging Path. 2014; 4(4): 355-360. [DOI:10.1016/j.biomag.2014.07.003]
3. Mehmood MH, Munir S, Khalid UA, Asrar M and Gilani AH. Antidiarrhoeal, antisecretory and antispasmodic activities of Matricaria chamomilla are mediated predominantly through K+-channels activation. BMC Complement. Altern. Med. 2015; 15(1): 1-9. [DOI:10.1186/s12906-015-0595-6]
4. Ghasemi M, Babaeian Jelodar N, Modarresi M, Bagheri N and Jamali A. Increase of chamazulene and α-bisabolol contents of the essential oil of German chamomile (Matricaria chamomilla L.) using salicylic acid treatments under normal and heat stress conditions. Foods 2016; 5(3): 56. [DOI:10.3390/foods5030056]
5. Cvetanović A, Švarc-Gajić J, Zeković Z, Jerković J, Zengin G, Gašić U, Tešić Ž, Mašković P, Soares C and Barroso MF. The influence of the extraction temperature on polyphenolic profiles and bioactivity of chamomile (Matricaria chamomilla L.) subcritical water extracts. Food Chem. 2019; 271: 328-337. [DOI:10.1016/j.foodchem.2018.07.154]
6. Srivastava JK, Shankar E and Gupta S. Chamomile: a herbal medicine of the past with a bright future. Mol. Med. Rep. 2010; 3(6): 895-901. [DOI:10.3892/mmr.2010.377]
7. Heidarianpour A, Mohammadi F, Keshvari M and Mirazi N. Ameliorative effects of endurance training and Matricaria chamomilla flowers hydroethanolic extract on cognitive deficit in type 2 diabetes rats. Biomed. Pharmacother. 2021; 135: 111230. [DOI:10.1016/j.biopha.2021.111230]
8. Maschi O, Cero ED, Galli GV, Caruso D, Bosisio E and Dell'Agli M. Inhibition of human cAMP-phosphodiesterase as a mechanism of the spasmolytic effect of Matricaria recutita L. J. Agric. Food Chem. 2008; 56(13): 5015-5020. [DOI:10.1021/jf800051n]
9. Gardiner P. Complementary, holistic, and integrative medicine: chamomile. Pediat. Rev. 2007; 28(4): e16-18. [DOI:10.1542/pir.28-4-e16]
10. Beringhs AO, Souza FM, de Campos AM, Ferraz HG and Sonaglio D. Technological development of Cecropia glaziovi extract pellets by extrusion-spheronization. Rev. Bras. Farmacogn. 2013; 23(1): 160-168. [DOI:10.1590/S0102-695X2012005000123]
11. Pápay ZE, Kállai-Szabó N, Ludányi K, Klebovich I and Antal I. Development of oral site-specific pellets containing flavonoid extract with antioxidant activity. Eur. J. Pharm. Sci. 2016; 95: 161-169. [DOI:10.1016/j.ejps.2016.10.029]
12. Chen T, Li J, Chen T, Sun CC and Zheng Y. Tablets of multi-unit pellet system for controlled drug delivery. J. Control. Rel. 2017; 262: 222-231. [DOI:10.1016/j.jconrel.2017.07.043]
13. Dudhamal S, Kawtikwar P, Nagoba S and Development. Formulation and evaluation of dispersible pellets of Lagenaria siceraria. Asian J. Pharm. Res. 2018; 6(4): 81-85. [DOI:10.22270/ajprd.v6i4.400]
14. Miliauskas G, Venskutonis P and Van Beek T. Screening of radical scavenging activity of some medicinal and aromatic plant extracts. Food Chem. 2004; 85(2): 231-237. [DOI:10.1016/j.foodchem.2003.05.007]
15. Kayumba PC, Huyghebaert N, Cordella C, Ntawukuliryayo JD, Vervaet C and Remon JP. Quinine sulphate pellets for flexible pediatric drug dosing: formulation development and evaluation of taste-masking efficiency using the electronic tongue. Eur. J. Pharm. Biopharm. 2007; 66(3): 460-465. [DOI:10.1016/j.ejpb.2006.11.018]
16. Alotaibi HF, Elsamaligy S, Mahrous GM, Bayomi MA and Mahmoud HA. Design of taste masked enteric orodispersible tablets of diclofenac sodium by applying fluid bed coating technology. Saudi Pharm. J. 2019; 27(3): 354-362. [DOI:10.1016/j.jsps.2018.12.003]
17. Mallipeddi R, Saripella KK and Neau SH. Use of fine particle ethylcellulose as the diluent in the production of pellets by extrusion-spheronization. Saudi Pharm. J. 2014; 22(4): 360-372. [DOI:10.1016/j.jsps.2013.11.001]
18. Jawed SH, Muhammad IN, Qazi F, Shoaib MH, Arshad HM and Siddiqui T. Development and Quality evaluation of sustained release pellets of eperisone HCl. Pak. J. Pharm. Sci. 2021; 34(1): 225-235.
19. Alshetaili AS, Almutairy BK, Alshahrani SM, Ashour EA, Tiwari RV, Alshehri SM, Feng X, Alsulays BB, Majumdar S and Langley N. Optimization of hot melt extrusion parameters for sphericity and hardness of polymeric face-cut pellets. Drug Dev. Ind. Pharm. 2016; 42(11): 1833-1841. [DOI:10.1080/03639045.2016.1178769]
20. Santos H, Veiga F, Pina M, Podczeck F and Sousa J. Physical properties of chitosan pellets produced by extrusion-spheronisation: influence of formulation variables. Int. J. Pharm. 2002; 246(1-2): 153-169. [DOI:10.1016/S0378-5173(02)00376-9]
21. Mehta S, De Beer T, Remon JP and Vervaet C. Effect of disintegrants on the properties of multiparticulate tablets comprising starch pellets and excipient granules. Int. J. Pharm. 2012; 422(1-2): 310-317. [DOI:10.1016/j.ijpharm.2011.11.017]
22. Bolourchian N, Nili M, Foroutan SM, Mahboubi A and Nokhodchi A. The use of cooling and anti-solvent precipitation technique to tailor dissolution and physicochemical properties of meloxicam for better performance. J. Drug Del. Sci. Tech. 2020; 55: 101485. [DOI:10.1016/j.jddst.2019.101485]
23. Bora D, Borude P and Bhise K. Taste masking by spray-drying technique. AAPS PharmSciTech. 2008; 9(4): 1159-1164. [DOI:10.1208/s12249-008-9154-5]
24. Samprasit W, Akkaramongkolporn P, Ngawhirunpat T, Rojanarata T and Opanasopit P. Formulation and evaluation of meloxicam oral disintegrating tablet with dissolution enhanced by combination of cyclodextrin and ion exchange resins. Drug Dev. Ind. Pharm. 2015; 41(6): 1006-1016. [DOI:10.3109/03639045.2014.922573]
25. Formisano C, Delfine S, Oliviero F, Tenore GC, Rigano D and Senatore F. Correlation among environmental factors, chemical composition and antioxidative properties of essential oil and extracts of chamomile (Matricaria chamomilla L.) collected in Molise (South-central Italy). Ind. Crops Prod. 2015; 63: 256-263. [DOI:10.1016/j.indcrop.2014.09.042]
26. Roby MHH, Sarhan MA, Selim KA-H and Khalel KI. Antioxidant and antimicrobial activities of essential oil and extracts of fennel (Foeniculum vulgare L.) and chamomile (Matricaria chamomilla L.). Ind. Crops Prod. 2013; 44: 437-445. doi: 10.1016/ j.indcrop.2012. 10.012. [DOI:10.1016/j.indcrop.2012.10.012]
27. Dadashpour M, Firouzi-Amandi A, Pourhassan-Moghaddam M, Maleki MJ, Soozangar N, Jeddi F, Nouri M, Zarghami N and Pilehvar-Soltanahmadi Y. Biomimetic synthesis of silver nanoparticles using Matricaria chamomilla extract and their potential anticancer activity against human lung cancer cells. Mater. Sci. Eng. C. 2018; 92: 902-912. [DOI:10.1016/j.msec.2018.07.053]
28. Thi THH, Lhafidi S, Carneiro SP and Flament M-P. Feasability of a new process to produce fast disintegrating pellets as novel multiparticulate dosage form for pediatric use. Int. J. Pharm. 2015; 496(2): 842-849. [DOI:10.1016/j.ijpharm.2015.09.049]
29. Chukwumezie BN, Wojcik M, Malak P and Adeyeye MC. Feasibility studies in spheronization and scale-up of ibuprofen microparticulates using the rotor disk fluid-bed technology. AAPS Pharm. Sci. Tech. 2002; 3(1): 10-22. [DOI:10.1208/pt030102]
30. Boutell S, Newton J, Bloor J and Hayes G. The influence of liquid binder on the liquid mobility and preparation of spherical granules by the process of extrusion/spheronization. Int. J. Pharm. 2002; 238(1-2): 61-76. [DOI:10.1016/S0378-5173(02)00064-9]
31. Muley S, Nandgude T and Poddar S. Extrusion-spheronization a promising pelletization technique: In-depth review. Asian J. Pharm. Sci. 2016; 11(6): 684-699. [DOI:10.1016/j.ajps.2016.08.001]
32. Shravani D, Lakshmi P and Balasubramaniam J. Preparation and optimization of various parameters of enteric coated pellets using the Taguchi L9 orthogonal array design and their characterization. Acta Pharm. Sin. B 2011; 1(1): 56-63. [DOI:10.1016/j.apsb.2011.04.005]
33. Akhter A and Kibria G. Effect of acrylic polymers on physical parameters of spheronized pellets using an aqueous coating system. Asian J. Pharm. 2014; 3(4): 292-298. [DOI:10.4103/0973-8398.59953]
34. Nasiri MI, Yousuf RI, Shoaib MH, Fayyaz M, Qazi F and Ahmed K. Investigation on release of highly water soluble drug from matrix-coated pellets prepared by extrusion-spheronization technique. J. Coat. Technol. Res. 2016; 13(2): 333-344. [DOI:10.1007/s11998-015-9749-1]

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | Journal of Medicinal Plants

Designed & Developed by : Yektaweb