Tekieh E, Rezazadeh S, Manaheji H, Akbari A, Zaringhalam J. The Effects of Pretreatment with
Achillea santolina and
Stachys athorecalyx Extracts on CFA-induced acute inflammation in male rats. J. Med. Plants 2010; 9 (34) :165-176
URL:
http://jmp.ir/article-1-304-en.html
1- Department of Physiology, Neuroscience Research Centre, Shahid Beheshti University of Medical Sciences
2- Institute of Medicinal Plants, ACECR
3- Department of Physiology, Neuroscience Research Centre, Shahid Beheshti University of Medical Sciences , jzaringhalam@yahoo.com
Abstract: (5747 Views)
Background: Inflammatory symptoms, hyperalgesia and edema, as a physiologic responses for stimulus can mediate via different mediators such as cytokines. Medicinal plants are an important source of substances which are claimed to induce anti-inflammatory effects. Objective: Regarding to these and on account of the Interlukine-6 roles in hyperalgesia and edema induction, the aim of this study explained to investigation of the pre-treatment effects of Achillea santolina and Stachys athorecalyx extracts on inflammation which induced by CFA in male Wistar rats. Methods: Methanolic and defatted extractions were done on aerial parts of the both plants: Achillea santolina and Stachys athorecalyx. 50, 100 and 200 mg/kg doses of extracts were selected for treatment. Results: Results indicated that pre-treatment with defatted and methanolic extracts of S. athorecalyx significantly decrease CFA-induced hyperalgesia and edema dose-dependently. At same situation only methanolic extract of A. santolina was effective in inflammatory signs reduction. Conclusion: It can concluded that A. santolina and S. athorecalyx extracts can be effective candidate for pre-treatment of inflammation, but the effective substances of them are different and need to be more investiged.
Keywords: Hyperalgesia,
Inflammation,
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Achillea santolina<,
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Stachys athorecalyx<,
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Extract,
CFA
Type of Study:
Research |
Subject:
Pharmacology & Toxicology Received: 2010/01/11 | Accepted: 2010/04/30 | Published: 2010/06/19