1- Department of Biochemistry, School of Medicine, Shahed University
2- Department of Physiology, Medicinal Plant and Neuroscience Research Center, School of Medicine, Shahed University , najafabady@yahoo.com
3- Department of Traditional Medicine, School of Medicine, Shahed University
4- Department of Physiology, School of Medicine, Shahed University
Abstract: (6484 Views)
Background: Learning and memory impairment during aging mind have a disturbance role in human life. Regarding to the defect mechanisms for prevention or treatment of memory loss, the new strategies were recommended for study on it. Objective: Importance of herbal medicine treatment encouraged us to examine the effect of a candidate plant Acorus calamus for improvement of learning and memory. Methods: Male rats were randomly divided to control and treatment groups. In treatment group the plant were applied to animals in oral (plant/ food ratio = % 6.25) for two weeks and in injected groups the plant extract were applied (i.p) to rat in 25, 50 and 100 mg/kg). Finally, all experimental animal groups were conducted to Y maze and shuttle box tests in order to obtain spatial recognition and acquisition – recalling data, respectively. Results: The step through latency (STL) time resulted from oral and 100 mg/kg injected dose groups show a significant difference with control animals. Also, alternation behavior (%) obtained from Y maze test data was marked than control rats. Conclusion: The present study show that oral and intraperitoneal administration of the extract in higher dose could have increase spatial recognition and recalling the data,
Type of Study:
Research |
Subject:
Pharmacology & Toxicology Received: 2008/06/25 | Accepted: 2009/11/11 | Published: 2010/06/19