:: Volume 3, Issue 35 (10-2010) ::
J. Med. Plants 2010, 3(35): 114-119 Back to browse issues page
Effects of Danae racemosa on Testosterone Hormone in Experimental Diabetic Rats
Sh Shahreari1, A Khaki *2, HR Ahmadi-Ashtiani3, Sh Rezazadeh4, R Hajiaghaei4
1- Department of Veterinary Pathology Islamic Azad University Yasooj Branch
2- Department of Veterinary Pathology Islamic Azad University Tabriz Branch , arashkhaki@yahoo.com
3- Biochemistry and Nutrition Department of Zanjan University of Medical Sciences, Zanjan, Iran & Department of Clinical Biochemistry, School of Medical Science, Tarbiat-e-Modarres University
4- Institute of Medicinal Plants, ACECR
Abstract:   (2426 Views)
Background: Danae racemosa is a strong antioxidant and antioxidants have significant effects on spermatogenesis, sperm biology and oxidative stress, and changes in antioxidant capacity are considered to be involved in the pathogenesis of chronic diabetes mellitus. Objective: Because STZ causes testicular dysfunction and degeneration under situations of experimentally induced diabetes in animal models, we aimed in this study Danae racemosa’s effects in decreasing the harmful effects of STZ on testicular and sperm functions b. Methods: Male Wistar rats (n = 40) were allocated into four groups: Group 1a: Control rats given 0.5 ml of 20% glycerol in 0.9% normal saline. Group 1b: Control rats given 0.5ml of 0.5 ml citrate buffer (pH4.0).Group 2: streptozotocin (STZ) treated rats. Group 3: rats given danae racemosa 400 mg/kg (gavage). Group 4: STZ treated rats given danae racemosa 400 mg/kg (gavage). Animals were kept in standard conditions. At 28 days after inducing diabetics, 5 mL blood was collected for measuring testosterone. Results: Total serum testosterone increased significantly in the group treated with danae racemosa (p < 0.05) compared with control groups. Testis weights in the diabetic groups decreased significantly in comparison with controls (p < 0.05). Conclusion: Danae racemosa had a significant protective effect on the diabetes-induced deteriorations in serum total testosterone, by reducing the levels of reactive oxygen species in serum. Therefore, it could be effective for maintaining healthy in diabetic rats.
Keywords: Danae racemosa, Diabet, Streptozotocin, Rat
Full-Text [PDF 155 kb]   (914 Downloads)    
Type of Study: Research | Subject: Clinical pathology
Received: 2014/10/21 | Accepted: 2014/10/21 | Published: 2014/10/21

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Volume 3, Issue 35 (10-2010) Back to browse issues page