:: Volume 2, Issue 50 (6-2014) ::
J. Med. Plants 2014, 2(50): 1-10 Back to browse issues page
A Analytical Review on Methods for the Isolation and Determination of Glycyrrhizic Acid from Glycyrrhiza glabra
M Khanahmadi1, H Naghdi Badi2, S Akhondzadeh3, F Khalighi–Sigaroodi2, A Mehrafarin2, S Shahriari1, R Hajiaghaee *4
1- ACECR, Kermanshah Branch
2- Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR
3- Tehran University of Medical Sciences
4- Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR , rhajiaghaee@yahoo.com
Abstract:   (6615 Views)
Glycyrrhiza glabra (Licorice) is a perennial shrub belongs to the Fabaceae family. It is widely used in food pharmaceutical products and tobacco industry because of its important secondary metabolites. Due to worldwide uses of licorice, it has significant role in export. One of the main bioactive compounds of the root is glycyrrhizic acid (GA) which is a saponine containing three carboxyl and five hydroxyl groups. Glycyrrhizic acid is used as an anti-inflammatory and anti-allergic remedy for the treatment of bronchial asthma, eczemas and other diseases. There are different methods for separation, purification, and analysis of glycyrrhizic acid (GA) from licorice roots. Most accepted technologies of them include using of solvents, water separation, polymeric macro porous resin and non-ionic surfactants. Also, high-performance liquid chromatography technique is the most important in analysis of GA.
Keywords: Glycyrrhiza glabra, Glycyrrhizin, Glycyrrhizic acid, Glycyrrhetinic acid, Purification and separation
Full-Text [PDF 296 kb]   (5556 Downloads)    
Type of Study: Review | Subject: Pharmacognosy
Received: 2014/09/26 | Accepted: 2014/09/26 | Published: 2014/09/26

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Volume 2, Issue 50 (6-2014) Back to browse issues page