سال 19، شماره 74 - ( 3-1399 )                   سال 19 شماره 74 صفحات 294-277 | برگشت به فهرست نسخه ها


XML English Abstract Print


1- گروه پزشکی، دانشکده پزشکی، واحد قم، دانشگاه آزاد اسلامی، قم، ایران ، dadkhah_bio@yahoo.com
2- پژوهشکده مواد و سوخت هسته ای، پژوهشگاه علوم و فنون هسته ای، تهران، ایران
3- گروه پاتوبیولوژی، دانشکده دامپزشکی،دانشگاه آزاد اسلامی، واحدگرمسار،گرمسار، ایران
4- دانشکده علوم پایه، دانشگاه حکیم سبزواری، سبزوار، ایران
5- دانشکده علوم پایه، دانشگاه آزاد اسلامی، واحد قم، قم، ایران
6- گروه گیاه شناسی، دانشگاه پیام نور، تهران، ایران
7- باشگاه پژوهشگران و نخبگان جوان، دانشگاه آزاد اسلامی واحد کرج، کرج، ایران
چکیده:   (3285 مشاهده)
مقدمه: سپسیس یا عفونت جزء دومین علت شایع مرگ و میر میان بیماران بستری در بخشهای مراقبتهای ویژه به شمار می‌رود. با توجه به عوارض ناشی از مصرف داروهای ضد‌التهابی غیر‌استروئیدی، استفاده از گیاهان دارویی دارای خاصیت ضد‌التهابی، مانند گل محمدی برای درمان و کاهش عوارض ناشی از التهاب، توصیه می‌شود. هدف: در این تحقیق اثرات ضدالتهابی و آنتی‌اکسیدانی اسانس گل محمدیRosa damascena Mill. در بافت ریه رت‌های سپتیکی شده در مدل تجربی التهابی CLP مورد ارزیابی قرار گرفت. روش بررسی: موش‌ها به پنج گروه کنترل منفی، کنترل مثبت و گروه‌های تیمار با اسانس گل محمدی و ایندومتاسین تقسیم شده و 24 ساعت پس از جراحی، پارامترهای دخیل در استرس اکسیداتیو اندازه‌گیری شدند. نتایج: سپسیس موجب کاهش FRAP و GSH و افزایش میزان LP، MPO، PGE2 و COX-2 شده، ولی بر روی GSTتأثیر معنی‌داری نداشت. اما، تیمار حیوانات با اسانس گل محمدی به صورت معنی‌داری در سطح این پارامتر‌های بیوشیمیایی مؤثر بوده است. همچنین، مطالعات پاتولوژی نشان می‌دهد که سپسیس منجر به ایجاد آسیب‌هایی در بافت ریه شده که این آسیب‌ها در اثر تیمار با اسانس گل محمدی کاهش یافته‌اند. نتیجه‌گیری: سپسیس موجب آسیب اکسیداتیو بافت ریه شده و استفاده از اسانس گل محمدی می‌تواند در جلوگیری و بهبود این آسیب‌ها مؤثر باشد.
متن کامل [PDF 1082 kb]   (1014 دریافت)    
نوع مطالعه: پژوهشی | موضوع مقاله: گياهان دارویی
دریافت: 1397/10/4 | پذیرش: 1398/2/21 | انتشار: 1399/4/31

فهرست منابع
1. Derek C, Angus MPH and van der Poll T. Severe sepsis and septic shock. N. Engl. J. Med. 2013; 369: 840-51. [DOI:10.1056/NEJMra1208623]
2. Sharma R and Vijayakumar M. Procalcitonin for improved assessment and an answer to sepsis dilemma in critically ill-a myth, a hype, or a reality? Nitte Univ. J. Health Sci. 2014; 4: 57-65.
3. Vincent JL, Marshall JC, Namendys-Silva SA, Francois B, Martin-Loeches I, Lipman J, Reinhart K, Antonelli M, Pickkers P, Njimi H, Jimenez E and Sakr Y. Assessment of the worldwide burden of critical illness: the intensive care over nations (ICON) audit. Lancet Respir. Med. 2014; 2: 380-6. [DOI:10.1016/S2213-2600(14)70061-X]
4. Gaieski DF, Edwards JM, Kallan MJ and Carr BG. Benchmarking the incidence and mortality of severe sepsis in the United States. Crit. Care Med. 2013; 41: 1167-74. [DOI:10.1097/CCM.0b013e31827c09f8]
5. Iskander KN, Osuchowski MF, Stearns-Kurosawa DJ, Kurosawa SH, Stepien D, Valentine C and Remick DG. Sepsis: multiple abnormalities, heterogeneous responses, and evolving understanding. Physiol. Rev. 2013; 93: 1247-88. [DOI:10.1152/physrev.00037.2012]
6. Dejager L, Pinheiro I, Dejonckheere E and Libert C. Cecal ligation and puncture: the gold standard model for polymicrobial sepsis? Trends Microbiol. 2011; 19 (4): 198-208. [DOI:10.1016/j.tim.2011.01.001]
7. Strong VEM, Mackrell PJ, Concannon EM, Naama HA, Schaefer PA, Shaftan GW, Stapleton PP and Daly JM. Blocking prostaglandin E2 after trauma attenuates pro-inflammatory cytokines and improves survival. Shock. 2000; 14: 374-9. [DOI:10.1097/00024382-200014030-00023]
8. Ritter C, Andrades M, FrotaJúnior ML, Bonatto F, Pinho RA, Polydoro M, Klamt F, Cleovaldo TS, Pinheiro CTS, Sérgio S, Menna-Barreto SS and José Cláudio F. Moreira JCF, Dal-Pizzol F. Oxidative parameters and mortality in sepsis induced by cecal ligation and perforation. Intensive Care Med. 2003; 29: 1782-9. [DOI:10.1007/s00134-003-1789-9]
9. Koksal GM, Sayilgan C, Aydin S, Oz H and Uzun H. Correlation of plasma and tissue oxidative stresses in intra-abdominal sepsis. J. Surg. Res. 2004; 122 (2): 180-3. [DOI:10.1016/j.jss.2004.07.246]
10. Lowes DA, Webster NR, Murphy MP and Galley HF. Antioxidants that protect mitochondria reduce interleukin-6 and oxidative stress, improve mitochondrial function, and reduce biochemical markers of organ dysfunction in a rat model of acute sepsis. BJA. 2013; 110 (3): 472-80. [DOI:10.1093/bja/aes577]
11. Dini S, Fatemi F, Rezaei MB, Dadkhah A, Dabbagh R. Considering the effect of gamma irradiation on chemical compositions and antioxidant activity of cumin seeds (Cuminum cyminum L.) essential oils. Applied Biology 2012; 2: 11-23.
12. Fatemi F, Dadkhah A, Rezaei M.B., Dini S. Effect of γ-irradiation on the chemical composition and antioxidant properties of cumin extracts. Food Biochem. 2013; 37(4): 432-439. [DOI:10.1111/j.1745-4514.2011.00641.x]
13. Dini S, Dadkhah A, Fatemi F. Biological properties of Iranian Zataria multiflora essential oils: a comparative approach. eJBio. 2015; 11 (3): 57-62.
14. Fatemi F, Dini S, Rezaei MB, Dadkhahd A, Dabbagh R, Naij S. The effect of γ-irradiation on the chemical composition and antioxidant activities of peppermint essential oil and extract. J. Essent. Oil Res. 2014; 26 (2): 97-104. [DOI:10.1080/10412905.2013.871670]
15. Dadkhah A, Khalaj GH, Fatemi F, Dini S, Hesaraki S, Naij S, Babbaei M, Attaran HR. The study of the role of barijeh (Ferula gummosa Boiss.) against hepatotoxicity induced by acetaminophen in the animal model. J. Med. Plants 2016; 15 (4): 14-23.
16. Roshanaei K, Dadkhah A, Fatemi F, Dini S. Heracleum persicum e oil administration in CCL4 treated rat sustains antioxidant / oxidative stress statue. Advances in Bioresearch. 2017; 8: 93-101.
17. Attaran HR, Dini S, Fatemi F, Hesaraki S, Parhizkarie M, Dadkhaha A. Hepatoprotective evaluation of Iranian Satureja Rechingeri essential oils against oxidative injuries induced by acetaminophen in wistar rats. Int. J. Rev. Life. Sci. 2015; 5(5): 204-210.
18. Dadkhah A, Fatemi F, Mohammadi Malayeri MR, Torabi, F, Sarbazi M, Dini S. Potential protective effect of pretreatment with caraway essential oil in vivo model of iron nanoparticle-induced liver injury. JMPB. 2018; 2: 145-152.
19. Dadkhah A, Khalaj Gh, Fatemi F, Dini S, Naij S, Fadaee Monfared M. Considering the effect of Golpar (Heracleum persicum) essential oils on the acute hepatotoxcity induced by acetaminophen in wistar rats. Journal of Animal Research. 2016; 29 (3): 292-306.
20. Roshanaei K, Dadkhah A, Fatemi, F and Dini S. The protective effects of Iranian golpar (Heracleum persicum) essential oil in liver damages induced by CCl4 in wistar rats. J. Med. Plants 2017; 1:110-122.
21. Hajhashemi V, Ghannadi A and Hajiloo M. Analgesic and anti-inflammatory effects of Rosa damascena hydroalcoholic extract and its essential oil in animal models. IJPR. 2010; 9: 163-8.
22. Yousefi B. Screening of Rosa damascena Mill. Landraces for flower yield and essential oil content in cold climates. Folia Hort. 2016; 28 (1): 31 40. [DOI:10.1515/fhort-2016-0005]
23. Kumar R, Sharma S, Sood S, Agnihotri VK and Singh B. Effect of diurnal variability and storage conditions on essential oil content and quality of damask rose (Rosa damascena Mill.) flowers in north western Himalayas. Sci Hortic. 2013; 154: 102-8. [DOI:10.1016/j.scienta.2013.02.002]
24. Akbari M, Kazerani HR, Kamrani A and Mohri M. A preliminary study on some potential toxic effects of Rosa damascena Mill. IJVR. 2013; 14 (3): 232-6.
25. Dadkhah A, Fatemi F, Mohammadi Malayeri MR, Karvin Ashtiyani MH, Kazemi Noureini S and Rasooli A. Considering the effect of Rosa damascena essential oil on oxidative stress and COX-2 gene expression in liver of septic rats. Turk. J. Pharm. Sci. 2019; 16 (4): 416-424. [DOI:10.4274/tjps.galenos.2018.58815]
26. Fatemi F, Golbodagh A, Hojihosseini R, Dadkhah A, Akbarzadeh K, Dini S and Mohammadi Malayeri MR. Anti-inflammatory effects of deuterium-depleted water plus Rosa damascene Mill. essential oil via cyclooxygenase-2 pathway in rats. Turk. J. Pharm. Sci. 2020, in press. [DOI:10.4274/tjps.galenos.2018.24381]
27. Achuthan CR, Babu BH and Padikkala J. Antioxidant and Hepatoprotective Effects of Rosa damascena. Pharmaceutical Biol. 2003; 41 (5): 357-61. [DOI:10.1076/phbi.41.5.357.15945]
28. Fatemi F, Allameh A, Khalafi H and Ashrafihelan J. Hepatoprotective effects of g-irradiated caraway essential oils in experimental sepsis. Appl. Radiat Isotopes. 2010a; 68: 280-5. [DOI:10.1016/j.apradiso.2009.10.052]
29. Fatemi F, Allameh A, Khalafi H, Rezaei MB and Seyhoon M. The effect of essential oils and hydroalcoholic extract of caraway seed on oxidative stress parameters in rats suffering from acute lung inflammation before and after γ-irradiation. J. Med. Aroma. Plant. 2010b; 25 (4): 441-55.
30. Fatemi F, Allameh A, Khalafi H, Rajaee R, Davoodian N and Rezaei MB. Biochemical properties of γ-irradiated caraway essential oils. J. Food Biochem. 2011; 35: 650 - 62. [DOI:10.1111/j.1745-4514.2010.00408.x]
31. Leite BL, Bonfim RR, Antoniolli AR, Thomazzi SM, Araújo AA, Blank AF, Estevam CS, Cambui EV, Bonjardim LR, Albuquerque Júnior RL and Quintans-Júnior L J. Assessment of antinociceptive, anti-inflammatory and antioxidant properties of cymbopogon winterianus leaf essential oil. Pharm. Biol. 2010; 48 (10): 1164-9. [DOI:10.3109/13880200903280000]
32. Rasooli A, Fatemi F, Hajihosseini R, Vaziri A, Akbarzadeh K, Mohammadi Malayeri MR, Dini S and Foroutanrad M. Synergistic effects of deuterium depleted water and Mentha longifolia L. essential oils on sepsis-induced liver injuries through regulation of cyclooxygenase-2. Pharmaceutical Biology 2019; 57 (1): 125-32. [DOI:10.1080/13880209.2018.1563622]
33. Yong-Hua Du, Rui-Zhang Feng, Qun Li, Qin Wei, Zhong-Qiong Yin, Li-Jun Zhou, Cui Tao, andRen-Yong Jia. Anti-inflammatory activity of leaf essential oil from cinnamomum longepaniculatum (Gamble) n. chao. Int. J. Clin. Exp. Med. 2014; 7 (12): 5612-20.
34. Wills ED. Lipid peroxide formation in microsomes: general consideration. Biochem. J. 1969; 113: 315-24. [DOI:10.1042/bj1130315]
35. Seldak J and Lindsay RH. Estimation of total protein bound and non-protein sulfidryl groups in tissue with Elman's reagent. Anal. Biochem. 1986; 25: 192-205. [DOI:10.1016/0003-2697(68)90092-4]
36. Habig WH, Pabst MJ and Jakoby WB. Glutathione s-transferases: the first enzymatic step in mercapturic acid formation. J. Biol. Chem. 1974; 25: 7130-9.
37. Benzie IFF and Strain JJ. The ferric reducing ability of plasma (FRAP) as a measure of antioxidant power: the FRAP assay. Anal. Biochem. 1996; 239: 70-6. [DOI:10.1006/abio.1996.0292]
38. Hillegass LM, Griswold DE, Brickson B and Albrightson-Winslow C. Assessment of myeloperoxidase activity in whole rat kidney. J. Pharmacol Methods 1990; 24: 285 - 95. [DOI:10.1016/0160-5402(90)90013-B]
39. Macdonald J, Galley HF and Webster NR. Oxidative stress and gene expression in sepsis. BJA. 2003; 90 (2): 221-32. [DOI:10.1093/bja/aeg034]
40. Victor VM and De La Fuente M. Immune cells redox state from mice with endotoxin-induced oxidative stress. Involvement of NF-κB. Free Radic. Res. 2003; 37 (1): 19-27. [DOI:10.1080/1071576021000038522]
41. Peralta JG, Llesuy S, Evelson P, Carreras MC, Flecha BG and Poderoso JJ. Oxidative stress in skeletal muscle during sepsis in rats. Circulatory Shock. 1993; 39 (2): 153-9.
42. Cuzzocrea S, McDonald MC, Mazzon E, Filipe HM, Lepore V, Terranova ML, Ciccolo A, Caputi AP and Thiemermann C. Beneficial effects of tempol, a membrane-permeable radical scavenger, on the multiple organ failure induced by zymosan in the rat. Crit. Care Med. 2001; 29 (1): 102-11. [DOI:10.1097/00003246-200101000-00022]
43. Alitonou GA, Avlessi F, Sohounhloue DK, Agnaniet H, Bessiere JM and Menut C. Investigations on the essential oil of Cymbopogon giganteus from Benin for its potential use as an anti-inflammatory agent. Int. J. Aromather. 2006; 16: 37-41. [DOI:10.1016/j.ijat.2006.01.001]
44. Dadkhah A and Fatemi F. Heart and kidney oxidative stress status in septic rats treated with caraway extracts. Pharmaceutical Biology 2011; 49 (7): 679-86. [DOI:10.3109/13880209.2010.539618]
45. Senol FS, Orhan IE, Kurkcuoglu M, Hassan Khan MT, Altintas A, Sener B and Can Baser KH. A mechanistic investigation on anticholinesterase and antioxidant effects of rose (Rosa damascena Mill). Food Res. Int. 2013; 53: 502-9. [DOI:10.1016/j.foodres.2013.05.031]
46. Saleh M, Clarck S, Woodard B, Deolu-Sobogun SA. Antioxidant and free radical scavenging activities of essential oils. Ethn. Dis. 2010; 20: 78-82.
47. Hsu DZ and Liu MY. Effects of sesame oil on oxidative stress after the onset of sepsis in rats. Shock. 2004a; 22 (6): 582-5. [DOI:10.1097/01.shk.0000135254.21699.45]
48. Hsu DZ, Li YH, Chien SP and Liu MY. Effects of sesame oil on oxidative stress and hepatic injury after cecal ligation and puncture in rats. Shock. 2004b; 21 (5): 466-9. [DOI:10.1097/00024382-200405000-00011]
49. Hsu DZ, Su SB, Chien SP, Chiang PJ, Li YH, Lo YJ and Liu MY. Effect of sesame oil on oxidative-stress-associated renal injury in endotoxemic rats: involvement of nitric oxide and proinflammatory cytokines. Shock. 2005; 24 (3): 276-80. [DOI:10.1097/01.shk.0000172366.73881.c7]
50. Bayir Y, Albayrak A, Can I, Karagoz Y, Cakir A, Suleyman H, Uyanik H, Yayla N, Polat B, Karakus E and Keles MS. Nigella sativa as a potential therapy for the treatment of lung injury caused by cecal ligation and puncture-induced sepsis model in rats. Cell. Mol. Biol. (Noisy-le-grand). 2012; 58 (2): 1680-7.
51. Hsu DZ, Chen KT, Chien SP, Li YH, Huang BM, Chuang YC and Liu MY. Sesame oil attenuates acute iron-induced lipid peroxidation-associated hepatic damage in mice. Shock. 2006b; 26 (6): 625-30. [DOI:10.1097/01.shk.0000232274.88354.8d]
52. Hsu DZ, Chien SP, Li YH, Chuang YC, Chang YC and Liu MY. Sesame oil attenuates hepatic lipid peroxidation by inhibiting nitric oxide and superoxide anion generation in septic rats. J. Parenter. Enteral Nutr. 2008; 32 (2): 154-9. [DOI:10.1177/0148607108314766]
53. Stark G. Functional consequences of membrane damage. J. Member Biol. 2005; 205 (1): 1-16. [DOI:10.1007/s00232-005-0753-8]
54. Podrez EA, Abu-Soud HM and Hazen SL. Myeloperoxidase-generated oxidants and atherosclerosis. Free Radic. Biol. Med. 2000; 28: 1717-25. [DOI:10.1016/S0891-5849(00)00229-X]
55. Zhang R, Brennan ML, Shen Z, Macpherson JC, Schmitt D, Cheryl Molenda Ch and Hazen SL. Myeloperoxidase functions as a major enzymatic catalyst for initiation of lipid peroxidation at sites of inflammation. The Journal of Biological Chemistry 2002; 277: 46116-22. [DOI:10.1074/jbc.M209124200]
56. Villa P, Saccani A and Sica A. Glutathione protects mice from lethal sepsis by limiting inflammation and potentiating host defense. J. Infect. Dis. 2002; 185: 1115-20. [DOI:10.1086/340042]
57. Stolf AM, dos Reis Lı'vero F, Dreifuss AA, Bastos-Pereira AL, Fabosi IA, de Souza CEA, de Oliveira Gomes L, Chicorski R, Brandt AP, Cadena SMS, Jose' Telles EQ, Hauser AB, Elferink RO, Zampronio AR and Acco A. Effects of statins on liver cell function and inflammation in septic rats. J. Surg. Res. 2012; 178 (2): 888-97. [DOI:10.1016/j.jss.2012.08.019]
58. Kim SJ, Yoon SJ, Kim YM, Hong SW, Yeon SH, Choe KI and Lee SM. HS-23, Lonicera japonica extract, attenuates septic injury by suppressing toll-like receptor 4 signaling. J. Ethnopharmacol. 2014; 155 (1): 256-66. [DOI:10.1016/j.jep.2014.05.021]
59. Yun N, Lee CH and Lee SM. Protective effect of Aloe vera on polymicrobial sepsis in mice. FCT. 2009; 47 (6): 1341-8. [DOI:10.1016/j.fct.2009.03.013]
60. Rios CEP, Abreu AG, Braga Filho JAF, Nascimento JR, Guerra RNM, Amaral FMM, Maciel MC and Nascimento FR. Chenopodium ambrosioides L. Improves phagocytic activity and decreases bacterial growth and the systemic inflammatory response in sepsis induced by cecal ligation and puncture. Front Microbiol. 2017; 8: 148. [DOI:10.3389/fmicb.2017.00148]
61. Surh YJ, Chun KS, Cha HH, Han SS, Keum YS, Park KK and Lee SS. Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-kappa B activation. Mutat. Res. 2001; 480-1: 243-68. [DOI:10.1016/S0027-5107(01)00183-X]
62. Pandey M, Prakash O, Santhi WS, Soumithran CS and Pillai RM. Overexpression of COX-2 gene in oral cancer is independent of stage of disease and degree of differentiation. Int. J. Oral Maxillofac. 2008; 37: 379-83. [DOI:10.1016/j.ijom.2008.01.004]
63. Oka T. Prostaglandin E2 as a mediator of fever: the role of prostaglandin e (EP) receptors. Front Bio. Sci. 2004; 9: 3046-57. [DOI:10.2741/1458]
64. Harirforoosh S, Asghar W and Jamali F. Adverse Effects of nonsteroidal antiinflammatory drugs: an update of gastrointestinal, cardiovascular and renal complications. J. Pharm. Pharm. Sci. 2013; 16 (5): 821-47. [DOI:10.18433/J3VW2F]
65. Wang HL, Li YX, Niu YT, Zheng J, Wu J, Shi GJ, Ma L, Niu Y, Sun T, Yu JQ. Observing anti-inflammatory and anti-nociceptive activities of glycyrrhizin through regulating COX-2 and pro-inflammatory cytokines expressions in mice. Inflammation 2015; 38: 2269-78. [DOI:10.1007/s10753-015-0212-3]

بازنشر اطلاعات
Creative Commons License این مقاله تحت شرایط Creative Commons Attribution-NonCommercial 4.0 International License قابل بازنشر است.