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:: دوره 1، شماره 37 - ( زبان: انگليسي- 1389 ) ::
جلد 1 شماره 37 صفحات 121-130 برگشت به فهرست نسخه ها
A Randomized, Double-blind, Placebo - controlled Study of Safety of the Adjunctive Saffron on Sexual Dysfunction Induced by a Selective Serotonin Reuptake Inhibitor
چکیده:   (2156 مشاهده)
Background: Recent studies have indicated potential of saffron for applying in a wide variety of diseases such as psychiatric and neurologic disorders. The concurrent use of saffron with SSRIs can lead to reducing the dose of SSRIs. Saffron at a dose of 200 mg may change some hematological and biochemical parameters. Objective: The goal of this trial was to assess the safety of concomitant administration of saffron and SSRI in patients with major depressive disorder (MDD). Methods: Twenty adult outpatients between 18 to 55 years-old with the diagnosis of MDD who were receiving an SSRI for at least 1 month prior to the initiation of the study entered this double-blind trial. They were randomly assigned to receive capsule of saffron (15 mg twice daily) or placebo. Some laboratory parameters were measured at baseline and week 4 of the study. Other side effects checked on a prepared list of side effects, were systematically recorded throughout the study at baseline and on a weekly basis. Results: Saffron as an add-on medication to SSRIs for 4 weeks did not cause any statistically significant changes in laboratory parameters including AST, ALT, ALP, BUN, Cr., FBS, TG, TC, WBC, RBC, Hgb, Ht, PT, INR, and Pl count. Conclusion: This preliminary study provides safety evidences of concurrent intake of saffron and SSRI.
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نوع مطالعه: مروري | موضوع مقاله: داروسازي
دریافت: ۱۳۹۳/۷/۲۶ | پذیرش: ۱۳۹۳/۷/۲۶ | انتشار: ۱۳۹۳/۷/۲۶
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Mansoori P, Akhondzadeh S, Raisi F, Ghaeli P, Jamshidi A, Nasehi A, et al . A Randomized, Double-blind, Placebo - controlled Study of Safety of the Adjunctive Saffron on Sexual Dysfunction Induced by a Selective Serotonin Reuptake Inhibitor. JMP. 2011; 1 (37) :121-130
URL: http://jmp.ir/article-1-239-fa.html

A Randomized, Double-blind, Placebo - controlled Study of Safety of the Adjunctive Saffron on Sexual Dysfunction Induced by a Selective Serotonin Reuptake Inhibitor. فصلنامه گياهان دارويي. 1389; 1 (37) :121-130

URL: http://jmp.ir/article-1-239-fa.html



دوره 1، شماره 37 - ( زبان: انگليسي- 1389 ) برگشت به فهرست نسخه ها
فصلنامه علمی پژوهشی گیاهان دارویی Journal of Medicinal Plants
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