سال 19، شماره 74 - ( 3-1399 )                   سال 19 شماره 74 صفحات 62-39 | برگشت به فهرست نسخه ها


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Zadeh Mehrizi T, Pirali Hamedani M, Ebrahimi Shahmabadi H, Mirzaei M, Shafiee Ardestani M, Haji Molla Hoseini M, et al . Effective materials of medicinal plants for leishmania treatment in vivo environment. J. Med. Plants 2020; 19 (74) :39-62
URL: http://jmp.ir/article-1-2381-fa.html
زاده مهریزی طاهره، پیرعلی همدانی مصطفی، ابراهیمی شاهم آبادی حسن، میرزایی مهدی، شفیعی اردستانی مهدی، حاجی ملاحسینی مصطفی، و همکاران. و همکاران.. ترکیبات مؤثره گیاهان دارویی اثربخش در درمان لیشمانیا در محیط درون‌تنی. فصلنامه گياهان دارویی. 1399; 19 (74) :39-62

URL: http://jmp.ir/article-1-2381-fa.html


1- بخش تحقیقات بالینی، انستیتو پاستور ایران، تهران، ایران
2- گروه فارماکوگنوزی، دانشکده داروسازی، دانشگاه علوم پزشکی تهران، تهران، ایران
3- گروه میکروبیولوژی، دانشکده پزشکی، دانشگاه علوم پزشکی رفسنجان، رفسنجان، ایران
4- معاونت آموزشی وزارت بهداشت، درمان و آموزش پزشکی، تهران، ایران
5- گروه رادیوفارماسی، دانشکده داروسازی، دانشگاه علوم پزشکی تهران، تهران، ایران
6- گروه ایمونولوژی پزشکی، دانشکده پزشکی، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران
7- مرکز آموزش و پژوهش بیماریهای پوست و جذام، دانشگاه علوم پزشکی تهران، تهران، ایران
8- بخش تغذیه، مرکز تحقیقات سرطان، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران
9- مرکزتحقیقات گیاهاندارویی،پژوهشکده گیاهان دارویی، جهاد دانشگاهی، کرج، ایرا
10- بخش تحقیقات بالینی، انستیتو پاستور ایران، تهران، ایران ، ametesramezani@gmail.com
چکیده:   (3815 مشاهده)
مقدمه: درمان لیشمانیوز به دلیل مشکلاتی از جمله قیمت و دوز بالای دارو ، مقاومت در برابر دارو و عوارض جانبی یک چالش به حساب میآید. هدف: هدف از این مطالعه، معرفی ترکیبات گیاهی می‌باشد که در محیط درون‌تنی خاصیت ضدلیشمانیایی آنها ثابت شده است. روش بررسی: در این مطالعه مروری در مورد مشتقات حاصل از گیاهان دارویی با کلمات کلیدی "داروهای گیاهی با اثرات ضدلیشمانیایی در محیط درون‌تنی، نانوحامل، آزمایشات بالینی، مکانیسم عملکرد" با جستجوی مقالات در پایگاه‌های اطلاعاتی معتبر تا سال 2018 بررسی گردید. در این مقاله، 14 ترکیب گیاهی با اثرات ضد لیشمانیازیس و همچنین مکانیسم عمل و اثر درمانی ترکیبات آنها مورد بررسی قرار گرفته است. نتایج: این مطالعه نشان داد که بعضی از این ترکیبات که فعالیت ضدلیشمانیایی کمی داشتند پس از بارگذاری در نانو حامل‌ها، فعالیت ضدلیشمانیایی آنها در محیط درون‌تنی به میزان چشمگیری افزایش یافته است. نتیجه‌گیری: این مطالعه نشان می‌دهد که ترکیبات موثره گیاهان دارویی بخصوص همراه با نانوحامل‌ها برای درمان لیشمانیا مورد توجه می‌باشند.
متن کامل [PDF 730 kb]   (1968 دریافت)    
نوع مطالعه: مروری | موضوع مقاله: گياهان دارویی
دریافت: 1397/9/11 | پذیرش: 1398/5/20 | انتشار: 1399/4/31

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