[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 4, Issue 68 (10-2018) ::
JMP 2018, 4(68): 136-144 Back to browse issues page
Phytochemical Study of Methanolic Extract of Ferula persica Willd. Inflorescence and its Antinociceptive Effect in Male Mice
S Nasri *1, M Ghorbani Nohooji2, Gh.R Amin3, AS Sharifi4, M Borbor4, F Shamohammadi4, M Moghaddasi4
1- Department of Biology, Payame Noor University, Tehran, Iran
2- Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
3- Department of Pharmacognosy, Pharmacy Faculty, Tehran University of Medical Sciences, Tehran, Iran
4- MSc of biology department, Payame noor Univ., Tehran, Iran
Abstract:   (411 Views)
Background: Nowadays treatment and control of pain is still one of problematic cases and syntetic analgesic drugs have several side effects.
Objective: The aim of this study is to investigate the antinociceptive effects and phytochemical analysis of Ferula persica with respect to side effects of chemical drugs.
Methods: The extract of plant inflorescence was prepared by percolation method. HPLC was used for phytochemical studies. In order to nociception test, male mice were used in acetic acid, immersion and formalin test. Mice were divided into experimental, control and positive control groups (receiving morphine) in each test.
Results: In phytochemical analysis, four flavonoids consist of Quercetin, Luteolin, Apigenin and Rutin were identified. In all 3 pain tests, the experimental group had a significant difference with control group (P<0.05), but there was no significant difference with morphine group (P>0.05).  
Conclusion: Methanolic extract of Ferula persica has antinociceptive effects, probably due to its sesquiterpenes and flavonoids.
Keywords: Antinociceptive, HPLC, Male mice, Methanolic extract of Ferula persica
Full-Text [PDF 520 kb]   (170 Downloads)    
Type of Study: Research | Subject: Biology
Received: 2018/09/29 | Accepted: 2018/09/29 | Published: 2018/09/29
Add your comments about this article
Your username or Email:


XML   Persian Abstract   Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Nasri S, Ghorbani Nohooji M, Amin G, Sharifi A, Borbor M, Shamohammadi F et al . Phytochemical Study of Methanolic Extract of Ferula persica Willd. Inflorescence and its Antinociceptive Effect in Male Mice. JMP. 2018; 4 (68) :136-144
URL: http://jmp.ir/article-1-2299-en.html

Volume 4, Issue 68 (10-2018) Back to browse issues page
فصلنامه علمی پژوهشی گیاهان دارویی Journal of Medicinal Plants
Persian site map - English site map - Created in 0.06 seconds with 32 queries by YEKTAWEB 3877