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:: Volume 4, Issue 68 (10-2018) ::
JMP 2018, 4(68): 41-48 Back to browse issues page
The Effect of Hydro-alcoholic Extracts of Anethum graveolens L. (Dill) on Amygdala Kindled in Rats
H Azhdari Zarmehri 1, B Kamalimanesh 2, Abarshi A 2, R Nafisi fard 3, E Mohebi 4, A Shamsizadeh 5, A Pezhhan 2, M Mohammad-Zadeh * 6
1- Neuroscience Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran
2- Cellular and Molecular Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran
3- Department of Zoology, Faculty of Biological Science, Shahid Beheshti University, Tehran, Iran
4- Student Research Comite, Sabzevar University of Medical Sciences, Sabzevar, Iran
5- Physiology Research Center, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
6- Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IRAN , mohammadzadehmh@mums.ac.ir
Abstract:   (67 Views)
Background: Although hydro-alcoholic extracts of Anethum graveolens L. had Anticonvulsants effect on PTZ-induced kindling seizure behavior, but on the amygdala kindling in rats induced seizure has not been investigated.
Objective: In this study, we evaluated the chronic effects of hydro-alcoholic extracts of Anethum graveolens L. on seizures using electrical amygdala kindling model.
Methods: Rats were divided into six groups. They were kindled by stimulating the amygdala by consecutive daily. Then, treated by hydro-alcoholic extracts of Anethum graveolens L. (i.p. 100, 200 and 400 mg/kg) and Afterdischarge Duration (ADD), Stage 4 latency (S4L) and Stage 5 duration (S5D) were recorded.
Results: Hydro-alcoholic extracts of Anethum graveolens L. (200 and 400 mg/kg) significantly increased stage 4 latency compare to the control group (P <0.05). Hydro-alcoholic extracts of Anethum graveolens L. (400 mg/kg) injection stage 5 duration caused by amygdala electrical kindling. Hydro-alcoholic extracts of Anethum graveolens L. (100, 200 and 400 mg/kg) injection significantly reduced ADD induced by amygdala kindling.
Conclusion: The data showed that injection of hydro-alcoholic extracts of Anethum graveolens L. has anti-epileptic effect and increases the time required for amygdala kindling and may have anticonvulsant effects.
 
Keywords: Anethum graveolens L., Amygdala Kindling, Epilepsy, Rat, Seizure
Full-Text [PDF 261 kb]   (38 Downloads)    
Type of Study: Research | Subject: Physiology
Received: 2018/09/29 | Accepted: 2018/09/29 | Published: 2018/09/29
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Azhdari Zarmehri H, Kamalimanesh B, A A, Nafisi fard R, Mohebi E, Shamsizadeh A, et al . The Effect of Hydro-alcoholic Extracts of Anethum graveolens L. (Dill) on Amygdala Kindled in Rats. JMP. 2018; 4 (68) :41-48
URL: http://jmp.ir/article-1-2291-en.html


Volume 4, Issue 68 (10-2018) Back to browse issues page
فصلنامه علمی پژوهشی گیاهان دارویی Journal of Medicinal Plants
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