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The Effect of 6 Weeks Swimming and Consumption of Zingiber officinale Roscoe Extract on some Inflammatory and Anti-inflammatory Factors in Heart Tissue of Mice Induced by Breast Cancer
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| B Vanaky1, N Shakeri *2, HA Nikbakht3, P Farzanegi4 |
1- PhD Student in Sport Physiology, Department of Physical Education and Sport Sciences, Sciences and Research Branch, Islamic Azad University, Tehran, Iran
2- Department of Physical Education and Sport Sciences, Sciences and Research Branch, Islamic Azad University, Tehran, Iran , nsprofsport@gmail.com
3- Department of Physical Education and Sport Sciences, Sciences and Research Branch, Islamic Azad University, Tehran, Iran
4- Department of Exercise Physiology, Sari Branch, Islamic Azad University, Sari, Iran |
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Abstract: (623 Views) |
Back ground: Heart disease is one of the side effects of breast cancer. Physical activity and herbs are effective in reducing the inflammatory factors of the heart tissue.
Objective: The purpose of this study was to evaluate the effect of 6 weeks of swimming and ginger on some inflammatory factors of the heart tissue of mice induced by breast cancer.
Methods: 60 female Balb C-female (6-8 weeks old) and (150-250 g weight) after induction of breast cancer (surgical technique) and familiarity with the environment were randomly divided into 6 groups: healthy control, control Cancer, Cancer-Swim, Cancer-Supplement, Cancer-Saline-Supplement and Cancer-Saline. Swimming and swimming-Supplement groups swam for 6 weeks, five days a week and 60 minutes a day. Supplements and supplements-swimming groups were injected 6 days a day with ginger extract (20 mg / kg) and saline (sodium chloride 0.9%). After intervention, alpha-Tumor necrosis levels (TNFα) and Interleukin10 (IL10) were measured by ELISA and specialized kits. One-way analysis of variance was used to analyze the data (P <0.05).
Results: The results showed that induction of cancer was associated with an increase in TNFα and a decrease in IL10. Six weeks of swimming, supplementation and combined intervention reversed these changes. But there is no significant difference between these three independent variables.
Conclusion: Swimming, supplementation of ginger and their combination may be effective in modulating inflammatory and anti-inflammatory factors in the heart tissue of breast cancer patients. |
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| Keywords: Breast cancer, Ginger supplemen, Heart tissue, Inflammation, Swimming |
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Full-Text [PDF 382 kb]
(259 Downloads)
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Type of Study: Research |
Subject:
Physiology
Received: 2018/09/29 | Accepted: 2018/09/29 | Published: 2018/09/29
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