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:: Volume 4, Issue 64 And S11 ((زبان: انگلیسی) 2018) ::
JMP 2018, 4(64 And S11): 59-75 Back to browse issues page
Long Term Effect of High Intensity Interval Training and Flaxseed Oil Supplementation on the Expression of Genes Involved in Reverse Cholesterol Transport in Male Rats
S Rahmati-Ahmadabad 1, H Shirvani 2, V Sobhani 3
1- (Ph.D.) Department of Physical Education, Pardis Branch, Islamic Azad University, Pardis, Iran
2- (Ph.D.) Exercise Physiology Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran
3- (M.D.) Exercise Physiology Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran
Abstract:   (63 Views)

Background: The potential effect of exercise training with supplementation in improving fat metabolism and complications of lipid disorders is an interesting subject.

Objective: The aim of this study was to investigate the effect of high intensity interval training and flax seed oil supplementation on liver and intestine ABCA1, SR-BI, ABCG1, LXR gene expression, as well as the concentration of HDL, LCAT and plasma lipids in male rats.

Methods: Forty adult Wistar rats were randomly divided into eight groups (n=5) including control-saline, training-saline, control-flaxseed oil (With 3 doses), and training-flaxseed oil. The training groups were given high-intensity interval training (10 weeks, five sessions in week) on a rodent treadmill at 90–95% of VO2max and supplement groups also received flaxseed oil with three different doses (10, 20 and 30 mg/kg per cage). Then rats were sacrificed and samples were collected.

Results: The results showed that the training created a significant increase (P<0.01) in the expression of liver ABCA1 and ABCG1genes, intestine ABCA1, LXR and SRBI genes, as well as the plasma HDL and LCAT concentration. Supplements caused a significant decrease (P<0.001) in expression of liver ABCA1 genes. There was a significant and positive correlation between liver ABCG1 gene expression with plasma HDL and LCAT, as well as between intestine LXR gene expression with plasma HDL.

Conclusion: Long-term consumption of even unsaturated oils may have adverse effects on the cardiovascular system, but high intensity interval training can bring health benefits by increasing the expression of genes involved in reverse cholesterol transport.

Keywords: High-Intensity Interval Training, Flaxseed Oil Supplement, Reverse Cholesterol Transport, ABCA1, ABCG1, LXR
Full-Text [PDF 423 kb]   (38 Downloads)    
Type of Study: Research | Subject: Sport physiology
Received: 2017/12/31 | Accepted: 2017/12/31 | Published: 2017/12/31
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Rahmati-Ahmadabad S, Shirvani H, Sobhani V. Long Term Effect of High Intensity Interval Training and Flaxseed Oil Supplementation on the Expression of Genes Involved in Reverse Cholesterol Transport in Male Rats. JMP. 2018; 4 (64) :59-75
URL: http://jmp.ir/article-1-1976-en.html
Volume 4, Issue 64 And S11 ((زبان: انگلیسی) 2018) Back to browse issues page
فصلنامه علمی پژوهشی گیاهان دارویی Journal of Medicinal Plants
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