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:: Volume 4, Number 64 (2017 2017) ::
JMP 2017, 4(64): 71-82 Back to browse issues page
Synchronic Effect of Curcumin and Swimming Training on Depression Level in Morphine Dependent Male Mice
L Elhampour1, MA Azarbayjani *2, M Nasehi3, M Piri2, MR Zarindast4
1- (Ph.D. Student) Department of Exercise Physiology, Islamic Azad University, Central Tehran Branch, Tehran, Iran
2- (Ph.D.) Department of Exercise Physiology, Islamic Azad University, Central Tehran Branch, Tehran, Iran
3- (Ph.D.) Department of Biology (Animal Physiology), Islamic Azad University, Tehran Medical Sciences Branch, Faculty of Medical New Technologies, Tehran, Iran
4- (Ph.D.) Department of Pharmacology School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Abstract:   (43 Views)
Background: There is need to more research because of extent drug trade in country and diversity of proposal cures such as non pharmacological ways including exercise and herbal supplements medicine.
Objective: The aim of this study was investigation of synchronic effect of Curcumin and swim training on depression in morphine dependent male mice.
Methods: In an experimental research, 40 Albino NMRI male mice with 19- 21 gr were selected as subjects and they were divide randomly to care groups of control, morphine, swim training, Curcumin, Swim training+ Curcumin. Subjects swam 60 min/day, 5 days/week for 1 week with receiving Curcumin. Then, they were taken morphine (2.5 mg/ml/kg) for 5 days with swim training. Therefore FST was done and after 10 days this test was taken again.
Results: Training increased swimming activity time, but it had no significant effect on immobility and climbing activities. At this period, Curcumin supplement caused increasing the time of climbing activities and no alteration in immobility and swimming times. Curcumin supplement with swim training caused increasing immobility time and decreasing swimming time, but it had no significant effect on climbing activities time.
Conclusion: The results of this research showed that morphine consumption didn’t cause depression. Also, combination of Curcumin supplement and swim training didn’t cause depression decreasing in morphine consumption term.
Keywords: Curcumin, Depression, Forced Swim Test, Morphine, Swim training
Full-Text [PDF 370 kb]   (17 Downloads)    
Type of Study: Research | Subject: Sport physiology
Received: 2017/11/7 | Accepted: 2017/11/7 | Published: 2017/11/7
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Elhampour L, Azarbayjani M, Nasehi M, Piri M, Zarindast M. Synchronic Effect of Curcumin and Swimming Training on Depression Level in Morphine Dependent Male Mice. JMP. 2017; 4 (64) :71-82
URL: http://jmp.ir/article-1-1910-en.html
Volume 4, Number 64 (2017 2017) Back to browse issues page
فصلنامه علمی پژوهشی گیاهان دارویی Journal of Medicinal Plants
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