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:: Volume 2, Issue 62 (6-2017) ::
JMP 2017, 2(62): 158-168 Back to browse issues page
The Protective Effect of Quercetin and it Nanocrystal on Anxiety-Like Behaviors Induced by Animal Model of Alzheimer’s Disease
A Hajizadeh Moghaddam *1, M Zare 2, S Rostamian 3, S Khanjani 4
1- (Ph.D.) 1- Department of Biology, Faculty of Basic Sciences, University of Mazandaran, Babolsar, Iran
2- (Ph.D.) 2- Faculty of Herb, Amol University of Special Modern Technologies, Amol, Iran
3- (M.Sc.) 1- Department of Biology, Faculty of Basic Sciences, University of Mazandaran, Babolsar, Iran
4- (Ph.D. Student) 3- Department of Physiology, Faculty of Biology Sciences, Shahid Beheshti University, Tehran, Iran
Abstract:   (610 Views)

Introduction: Alzheimer is a neurodegenerative disease which is characterized by progressive memory loss, diminished cognitive ability and behavioral disturbances such as anxiety-like behaviors. Quercetin is a polyphenolic compound with antioxidant and neuroprotective effects.

Objective: Purpose of this study is evaluated anxiolytic effect of quercetin and its nanocrystal in model of Alzheimer’s disease.

Methods: In this experimental study, forty-nine male rats were randomly divided into seven groups, as follows: control group (intact rats), vehicle (received distilled water orally and intrcerebroventricullary), disease (received 10µg/rat STZ intracerebroventricularly and distilled water orally) and disease treated groups (received quercetin and its nanocrystal at doses of 10 and 25 mg/kg/day orally for four weeks after injection of STZ). Elevated plus maze (EPM) test was used to assess anxiety-­like behaviors.

Results: Results indicated that icv-STZ injection significantly decrease percent of open arm times (%OAT) and percent of open arm enters (%OAE) in the EPM test (P<0.001) and treatment with the quercetin and its nanocrystal significantly increased these behavioral indexes in the end of third and fourth weeks (P<0.001). Furthermore, treatment with quercetin nanocrystal increased %OAT and %OAE more than the quercetin.

Conclusion: This study showed the protective effect of quercetin and its nanocrystal in the prevention of anxiogenic-like behaviors induced by Alzheimer’s model of rat and treatment with quercetin nanocrystal was more effective than quercetin.

Keywords: Alzheimer, Anxiety, Rat, Streptozotocin, Quercetin nanocrystal
Full-Text [PDF 420 kb]   (138 Downloads)    
Type of Study: Research | Subject: Physiology
Received: 2017/05/27 | Accepted: 2017/05/27 | Published: 2017/05/27
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Hajizadeh Moghaddam A, Zare M, Rostamian S, Khanjani S. The Protective Effect of Quercetin and it Nanocrystal on Anxiety-Like Behaviors Induced by Animal Model of Alzheimer’s Disease. JMP. 2017; 2 (62) :158-168
URL: http://jmp.ir/article-1-1740-en.html
Volume 2, Issue 62 (6-2017) Back to browse issues page
فصلنامه علمی پژوهشی گیاهان دارویی Journal of Medicinal Plants
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