year 16, Issue 61 And S10 (supplement 10 2017)                   J. Med. Plants 2017, 16(61 And S10 ): 156-166 | Back to browse issues page

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Effect of Kombucha Tea on Depression and Motor Activity in Mice. J. Med. Plants. 2017; 16 (61) :156-166
Abstract:   (4197 Views)

Background: Depression is a threatening disease. Due to adverse effects of chemical antidepressant drugs, researcher’s attention has been shifted toward natural drug.

Objective: In this work, the antidepressant effect of Kombucha tea (KT) evaluated against reserpine induced depression in mice.

Methods: In this experimental study, 42 male mice were randomly divided into 6 groups of 7 mice. Vehicle mice received normal saline (1 mg/kg, i.p.), negative and positive control groups received reserpine (5mg/kg, i.p.) and fluoxetine (20 mg/kg, i.p.) respectively and treatment groups received Kombucha tea at doses of 250, 500, 1000 mg/kg, 18 h after administration of reserpine. Mice were then tested with forced swimming and rotarod tests. At the end of behavioral tests, blood sample were collected and used to assess blood antioxidant capacity.

Results: There was significant difference in the duration of immobility time between vehicle and reserpine treated groups (P<0.001). Administration of Kombucha tea at doses of 250, 500 and 1000 mg/kg into depressed mice significantly reduced the duration of immobility time. KT administration significantly improved blood antioxidant capacity of mice blood.

Conclusion: These results provide support for the potential antidepressant effects of Kombucha tea against.

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Type of Study: Research | Subject: Pharmacology & Toxicology
Received: 2015/10/11 | Accepted: 2016/08/13 | Published: 2017/02/13

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