Aloe vera Leaf Gel in Treatment of Advanced Type 2 Diabetes Mellitus Needing Insulin Therapy: A Randomized Double-Blind Placebo-Controlled Clinical Trial
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چکیده: (2640 مشاهده) |
Background: Advanced type 2 diabetes mellitus (T2DM) needing
insulin therapy is a common disease. Previous studies indicate that aloe (Aloe
vera L.) leaf gel may positively affect the blood glucose and lipid levels
in patients with advanced T2DM needing insulin. Objective: Evaluation of the efficacy and safety of aloe leaf
gel in the treatment of type 2 diabetic patients resistant to oral synthetic
anti-hyperglycemic drugs needing insulin. Methods: In this randomized double - blind placebo-controlled
clinical trial with the patients aged 40-60 years, the efficacy and safety of
taking aloe leaf gel (one 300 mg capsule every 12 hours for 2 months) combined
with oral synthetic anti-hyperglycemic drugs in treatment of 35 patients were
evaluated and compared with the placebo group (n = 35). Results: The aloe leaf gel lowered the blood levels of fasting
glucose and glycosylated hemoglobin significantly (p = 0.041 and p = 0.023
respectively) without any significant effects on the lipid profile and
liver/kidney function tests (p > 0.05) compared with placebo at the
endpoint. No adverse effects were reported. Conclusion: The
results suggest that aloe leaf gel may safely improve glycemic control in
patients with advanced T2DM needing insulin. |
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متن کامل [PDF 227 kb]
(1126 دریافت)
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نوع مطالعه: پژوهشي |
موضوع مقاله:
فارماكولوژي دریافت: ۱۳۹۳/۷/۱۳ | پذیرش: ۱۳۹۳/۷/۱۳ | انتشار: ۱۳۹۳/۷/۱۳
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