Background: Nowadays, liver disorders are one of the most serious and threatening problems of the health. Persian Golpar (Heracleum (H.) persicum) as an endemic medicinal plant with antioxidant and anti-inflammatory properties was  used (noted)  in the study for reducing the live injuries.

Objective: This experiment –for the first time- was conducted to consider the effects of the oils obtained from fruits of Persian Golpar on the liver toxicity induced by the injection of tetrachloride carbon (CCl4) in the Wistar rats.

Methods: In this study, 100 male Wistar rats were divided into 20 groups (n=5). Negative control group (NC) received DMSO and olive oil for two weeks and the positive control group (C) received DMSO as i.p injection in 14 days following CCl4 (2 ml/kg b.w) at day 15^th. The standard group (BHT), The treatment groups received H. persicum essential oils at both doses 100 and 200 mg/kg b.w as i.p injection following CCl4 (2 ml/kg b.w) at day 15^th. Then, the levels of the glutathione (GSH), total antioxidant capacity of plasma (FRAP), proxidasion lipids (MDA) and glutathione s-transferase (GST) and also liver enzymes for instance alanin teransferase (ALT) and aspartate teransferase (AST) were estimated at 4, 8, 16 and 24 h after CCL4 injection.

Results: The injection of the essential oils (at the both doses) obtained from Persian Golpar could surprisingly modulate the changes of the antioxidant/oxidative parameters as well as liver enzymes induced by CCL4 administration.

Conclusion: These results indicated the protective effect of Iranian Golpar essential oils on the liver. These effects are probably due to its antioxidant capacity.