en گياهان دارویی Medicinal Plants پژوهشی Research <div style="text-align: justify;"><b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">Background:</span></span></span></b> <span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Many medicinal plants contain natural chemicals that have therapeutic effects for the management and treatment of coughs. In many rural communities in Nigeria, reliance on traditional medicine for the management of respiratory conditions is common. <b>Objective: </b>This study aimed to investigate locally available medicinal plants used by herbalists for the treatment of cough in Ogun and Oyo states, southwestern Nigeria. <b>Methods: </b>An ethnobotanical survey was conducted among 200 participants, mainly traditional healers and herblists, selected from major markets in Ogun and Oyo states. Structured questionnaires were used to collect demographic data and plant characteristics. Demographic data were summarized using descriptive statistics, while relative frequency of citation (RFC), and use value (UV) indices were used to analyze plant characteristics. <b>Results:</b> The mean age of the 200 study participants was 46.0 &plusmn; 9 years of which 36.5 % (73) were male and 63.5 % (127) were female. A total of 25 plant species from 20 families were identified for cough treatment. The most commonly used species were <i>Anacadium occidentale </i>(RFC = 0.21), <i>Garcinia kola</i> (RFC = 0.18), and <i>Cola acuminata</i> (RFC = 0.18). <i>Adansonia digitata</i> recorded the highest UV of 0.04. Leaves (36 %), bark (17 %), and stem (17 %) were the most commonly used plant parts. Concoction (32 %), decoction (20 %) and maceration (20 %) were the main preparation methods, while oral administration (100 %) was the most common mode of consumption. <b>Conclusion: </b>This study provided insight into indigenous knowledge of herbal cough remedies in southwestern Nigeria.</span></span></div> Multiple sclerosis, Cuprizone, P. oleracea, Demyelination, Nrf2, NF-kB 17 29 http://jmp.ir/browse.php?a_code=A-10-7261-1&slc_lang=en&sid=1 Okikiola Oyeniyi oyeniyiokikiola@gmail.com 100319475328460050183 100319475328460050183 No Department of Biological Sciences, Tai Solarin University of Education (TASUED), Nigeria Ojore Godday Aghedo oaghedo@cphinigeria.org 100319475328460050184 100319475328460050184 Yes Research Department, Center for Population Health Initiative (CPHI), Nigeria Chris Oluseye Olusegun Olusegun931@gmail.com 100319475328460050185 100319475328460050185 No College of Health, Science and Society, University of the West of England (UWE), United Kingdom Chukwuebuka Peter Kelvin Uwaoma ukelvin@cphing.org 100319475328460050186 100319475328460050186 No Research Department, Center for Population Health Initiative (CPHI), Nigeria Victoria Olabisi olabisivictoria302@gmail.com 100319475328460050187 100319475328460050187 No Lagos State University College of Medicine (LASUCOM), Nigeria