year 6, Issue 24 (12-2007)
J. Med. Plants 2007, 6(24): 17-21 |
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Zaringhalam M, Sattari M, Zaringhalam J, Rezazadeh S. Effect of Black Pepper, Red Pepper and Zataria multiflora Boiss. Alcoholic Extracts on Growth and DNase Activity of Staphylococcus aureus. J. Med. Plants 2007; 6 (24) :17-21
URL: http://jmp.ir/article-1-545-en.html
URL: http://jmp.ir/article-1-545-en.html
1- Department of Bacteriology, Medical Sciences School, Tarbiat Modares University, Tehran, Iran , sattarim@modares.ac.ir
2- Department of Bacteriology, Medical Sciences School, Tarbiat Modares University, Tehran, Iran
3- Neuroscience Center, Department of Physiology, Shahid Beheshti Medical University, Tehran, Iran
4- Department of Pharmacognosy and Pharmaceutics, Institue of Medical Plant and Natural Products (ACECR), Tehran, Iran
2- Department of Bacteriology, Medical Sciences School, Tarbiat Modares University, Tehran, Iran
3- Neuroscience Center, Department of Physiology, Shahid Beheshti Medical University, Tehran, Iran
4- Department of Pharmacognosy and Pharmaceutics, Institue of Medical Plant and Natural Products (ACECR), Tehran, Iran
Abstract: (6596 Views)
Background: Staphylococcus aureus is one of the most frequently identified pathogens in clinical laboratories and DNase is its important virulence factor. This enzyme is capable of destroying deoxyribonucleic acid (Willett etal., 1988). There are lots of antibacterial agents that can prevent the production of this enzyme. Staphylococcus aureus can develop drug resistance to many chemical drugs so considerable effort has been expanded by investigators in the development of herbal drugs. Black pepper, Red pepper and Zataria multiflora Boiss. are some herbal drugs that have been used in cure of infections. Objectives: In this study, the alcoholic extract of Black pepper, Red pepper and Zataria multiflora Boiss. was tested for antibacterial activity against Staphylococcus aureus. Methods: Black pepper, Red pepper and Zataria multiflora Boiss. were provided from Iranian agricultural researches center.2gr of each plant powder was added to10cc ethanol 96°. After 24hours, the crude extract was separated as an alcoholic extract and concentrated by distillation method. Results: The antibacterial activity against Staphylococcus aureus was examined and the results showed that all the extracts were effective. The extracts that showed antimicrobial activity were later tested to determine the Minimum Inhibitory Dilution (MID) for Staphylococcus aureus. They were also effective on the inhibition of DNase activity. The inhibition against DNase activity was observed at the dilutions lower than the minimum inhibitory dilution (MID) of each extract. Conclusion: The results of this study showed that Black pepper, Red pepper and Zataria multiflora Boiss. extracts can play a significant role in inhibition of Staphylococcus aureus and they can inhibit release of the DNase enzyme.
Keywords: Staphylococcus aureus, DNase activity, Black pepper, Red pepper, Zataria multiflora Boiss.
Type of Study: Research |
Subject:
Pharmacognosy & Pharmaceutics
Received: 2006/09/21 | Accepted: 2007/08/25 | Published: 2007/12/21
Received: 2006/09/21 | Accepted: 2007/08/25 | Published: 2007/12/21
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