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:: Volume 3, Number 63 (زبان: انگليسي 2017) ::
JMP 2017, 3(63): 68-77 Back to browse issues page
Clinical Efficacy of Topical Avena sativa Versus Betamethasone in Chronic Pruritus due to Sulfur Mustard Exposure
M Shohrati *1, M Davoud2, Sh Rezazadeh3, B Najafian4
1- (Pharm.D.) 1- Research Center of Chemical Injuries, Baqiatallah University of Medical Sciences, Tehran, Iran
2- (M.D.) 2- Department of Dermatology, Baqiatallah University of Medical Sciences, Tehran, Iran
3- (Ph.D.) 3- Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
4- (M.D.) 4- Department of Pediatrics, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, IR Iran
Abstract:   (189 Views)
Background: Avena sativa, a well-known herbal medicine; has been used in various skin diseases such as eczema, burn and pruritus.
Objective: The objective of this study was to evaluate the effect of this herbal medicine for treatment of chronic pruritus in Sulfur Mustard (SM) exposed patients.
Methods: Veterans who referred to Baghiat-Allah dermatologic clinic for itching problems were examined by a dermatologist and randomly assigned in three different groups. Group A received ointment derived from Avena sativa plant, group B, placebo and group C, betamethasone 0.1% cream twice a day for 4 weeks. Twenty five patients were included in each group. A visual analogue scale were used for assessment of severity of pruritus and 2 questionnaire for quality of life and quality of sleep were filled for each patient.  
Results: Pruritus severity after the study by VAS method was significantly decreased in all the groups, but betamethasone group showed the largest decrease (-2.4, P<0.001). The average quality of life based on DLQI criteria and quality of sleep based on PSQI after the treatment showed the most significant difference in betamethasone group (3.52, P<0.001 and  0.96, P=0.001 respectively). Although Avena sativa showed significant effect on these criteria but it was only superior to placebo and not as effective as betamethasone.
 
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Conclusion: The result demonstrated that Avena sativa ointment reduced chronic pruritus, increased quality of life and quality of sleep in patients exposed to SM but betamethasone was superior in all aspects.
Keywords: Avena sativa, Chronic pruritus, Sulfur mustard
Full-Text [PDF 145 kb]   (50 Downloads)    
Type of Study: Research | Subject: Chemistry
Received: 2017/08/26 | Accepted: 2017/08/26 | Published: 2017/08/26
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Shohrati M, Davoud M, Rezazadeh S, Najafian B. Clinical Efficacy of Topical Avena sativa Versus Betamethasone in Chronic Pruritus due to Sulfur Mustard Exposure. JMP. 2017; 3 (63) :68-77
URL: http://jmp.ir/article-1-1833-en.html
Volume 3, Number 63 (زبان: انگليسي 2017) Back to browse issues page
فصلنامه علمی پژوهشی گیاهان دارویی Journal of Medicinal Plants
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