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:: Volume 4, Number 60 (11-2016) ::
JMP 2016, 4(60): 39-46 Back to browse issues page
The Effect of Hydro-alcoholic Extract of Licorice (Glycyrrhiza glabra) Rhizome on the Isolated Ileum of Male Rats and its Interaction with Nitrergic System
Abstract:   (685 Views)

Background: The licorice (Glycyrrhiza glabra) rhizome has been widely used in traditional medicine for treatment of gastrointestinal diseases.

Objective: In the present study, the effect of hydro-alcoholic extract of licorice rhizome on mechanical activity of isolated ileum of male rats has been studied.

Methods: Seven adult male rats were anesthetized by ethyl ether, their abdomen opened, and ileum dissected and divided into 1 cm segments. The segments were connected to a force transducer longitudinally and inserted to an organ bathe contained oxygenated Tyrode solution (37 °C, pH=7.4). Their mechanical activity of ileum was recorded by power lab AD instrument in basal condition, and after administration of L-NAME (10-4M) drug in the presence and absence of licorice rhizome extract (0.0175 mg/ml). Also the mechanical activity of control group segments were recorded at the same condition with extract solvent (ethanol %70).

Results: A significant decrease in mechanical activity of the isolated ileum occurred after administration of hydro-alcoholic extract of licorice compared to the control group, while the mechanical activity of ileum tissue not significantly changed in the coadministration of L-NAME and extract between experimental and control groups.

Conclusion: We can conclude that hydro-alcoholic extract of licorice has modifying effect on ileum motility, and this activity may be occurred independently to the nitrergic system.

Keywords: Glycyrrhiza glabra, Ileum, Nitric oxide
Full-Text [PDF 371 kb]   (386 Downloads)    
Type of Study: Research | Subject: Physiology
Received: 2016/11/1 | Accepted: 2016/11/1 | Published: 2016/11/1
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The Effect of Hydro-alcoholic Extract of Licorice (Glycyrrhiza glabra) Rhizome on the Isolated Ileum of Male Rats and its Interaction with Nitrergic System. JMP. 2016; 4 (60) :39-46
URL: http://jmp.ir/article-1-1498-en.html
Volume 4, Number 60 (11-2016) Back to browse issues page
فصلنامه علمی پژوهشی گیاهان دارویی Journal of Medicinal Plants
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