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:: Volume 4, Number 60 (11-2016) ::
JMP 2016, 4(60): 24-38 Back to browse issues page
A Review on Antidepressant Effects Medicinal Plants with Emphasis on their Mechanisms of Action
Abstract:   (1262 Views)

Background: Depression is a serious, debilitating and common illness among various social groups. Chemical and synthetic drugs available for the disease have numerous side effects and result only around a 50% full recovery.

Objectives: Today, researchers are trying to find new and affordable drugs without serious side effects. Medicinal plants showed considerable pharmacological effects in the treatment of depression in different experimental models.

Methods: In this study, articles from journals indexed in the Scopus, PubMed, Information Sciences Institute (ISI), and Scientific Information Database (SID) were reviewed.

Results: A review of studies in this field showed that most medicinal plants show anti-depressant effects through regulating of the synaptic serotonin and dopamine, regulation of the hypothalamic-pituitary-adrenal axis activity, strengthening of the body's antioxidant defenses and reducing of the inflammatory mediators.

Conclusion: medicinal plant and their component show protective effect against depression through different mechanism. Medicinal plants can be used as a new source for the development of anti-depressant drugs.

Keywords: Depression, Mechanisms of influence, Medical plants
Full-Text [PDF 286 kb]   (693 Downloads)    
Type of Study: Research | Subject: Biochemistry
Received: 2016/11/1 | Accepted: 2016/11/1 | Published: 2016/11/1
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A Review on Antidepressant Effects Medicinal Plants with Emphasis on their Mechanisms of Action. JMP. 2016; 4 (60) :24-38
URL: http://jmp.ir/article-1-1497-en.html
Volume 4, Number 60 (11-2016) Back to browse issues page
فصلنامه علمی پژوهشی گیاهان دارویی Journal of Medicinal Plants
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