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:: Volume 4, Number 56 (12-2015) ::
JMP 2015, 4(56): 115-122 Back to browse issues page
Effect of Calligonum Comosum on Ovarian Histology of Polycystic Ovary Mouse Model
L Amini1, N Tehranian *2, M Movahedin3, F Ramezani Tehrani4
1- (Ph.D. student) 1- PhD candidate of Reproductive Health, Department of Midwifery and Reproductive Health, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
2- (Ph.D.) 2- Department of Midwifery and Reproductive Health, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran , tehranian@modares.ac.ir
3- (Ph.D.) 3- Department of Anatomical Sciences, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
4- (M.D.) 4- Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences
Abstract:   (1560 Views)

Background: Increased oxidative stress in women with polycystic ovary syndrome attracted attentions to antioxidant treatments. Calligonum Comosum is a planet with antioxidant propertis.

Objective: This study aimed to investigating Calligonum effect on polycystic ovarian histology of polycystic ovary mouse model.

Methods: Thity two female NMRI mice with 25-30 gr weight and 8 weeks age were investigated. A single dose of estradiol valerate (40 mg/kg; im) was used for induce polycystic ovarian morphology. Calligonum Comosom extract (20 mg/kg/ week; ip) was injected for 4 consequent weeks. In sham group, only DMSO was used. After 4 weeks, blood and histological samples were prepared to study.

Results: There was no significant effect of 20 mg/kg Calligonum on polycystic ovarian morphology mouse model.

Conclusion: The effect of other doses of Calligonum Comosum on fertility or adverse effect of this planet need to be more investigated.

Keywords: Calligonum Comosum, Animal model of polycystic ovary, Eskanbil, Polycystic ovarian morphology
Full-Text [PDF 366 kb]   (692 Downloads)    
Type of Study: Research | Subject: Midwifery
Received: 2016/02/14 | Accepted: 2016/02/14 | Published: 2016/02/14
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Amini L, Tehranian N, Movahedin M, Ramezani Tehrani F. Effect of Calligonum Comosum on Ovarian Histology of Polycystic Ovary Mouse Model. JMP. 2015; 4 (56) :115-122
URL: http://jmp.ir/article-1-1231-en.html
Volume 4, Number 56 (12-2015) Back to browse issues page
فصلنامه علمی پژوهشی گیاهان دارویی Journal of Medicinal Plants
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